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Annals of Military and Health Sciences Research
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Association of estrogen receptor 1 rs9340799 polymorphism with implantation failure in Iranian infertile women
Author(s):
1Clinic of IVF and Infertility Treatment, Besat Hospital, Tehran, Iran., Andorra
2Clinic of IVF and Infertility Treatment, Besat Hospital, Tehran, Iran, Andorra
*Corresponding Author: Corresponding author: Hadi Mirzapour-Delavar , Clinic of IVF and Infertility Treatment, Besat Hospital, Tehran, Iran., Andorra Email: [email protected]
Published online:Sep 25, 2014
Article type:Research Article
Received:Jul 23, 2014
Accepted:Aug 22, 2014
How to Cite:Mirzapour-Delavar H, Shafighian A, Shahidi Z. Association of estrogen receptor 1 rs9340799 polymorphism with implantation failure in Iranian infertile women. Ann Mil Health Sci Res. 2014;12(3):e63283. doi:
Abstract
Materials and Methods: Hundred two infertile women with at least one IVF failure were enrolled in the study as the case group and 112 healthy women as the control group. The restriction fragment length of polymorphism method was performed for genotyping the single nucleotide polymorphism rs9340799 (A/G XbaI) located in intron 1 of ESR1 gene. The result was confirmed by DNA sequencing analysis.
Results: The genotype distribution of AA in case and control groups was 40 (39.2%) and 55 (49.1%), respectively. However, genotype distribution of AG was 41 (40.2%) and 47 (41.9%). Ultimately genotype distribution of GG was 21 (20.6%) and 10 (9%). There was a statistically significant difference between case and control groups in the genotype distribution of XbaI polymorphism (P = .04).
Conclusion: There was an association between single nucleotide polymorphism ESR1 rs9340799 and implantation failure in Iranian infertile women who underwent IVF procedure.
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© 2014, Annals of Military and Health Sciences Research. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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