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Annals of Military and Health Sciences Research
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The most sensitive double-marker method of cardiac isoenzymes of creatinine kinase, troponin I, and myoglobin in different time periods for diagnosing acute myocardial infarction
Author(s):
1Department of Biochemistry, Bessat General Hospital, Aja University of Medical Sciences, Tehran, Iran, Andorra
2Private Practice of Urology and Andrology, Tehran, Iran, Andorra
*Corresponding Author: Corresponding author: Mohammad Reza Safarinejadi Aghdam, Private Practice of Urology and Andrology, Tehran, Iran, Andorra Email: [email protected]
Published online:Jan 22, 2014
Article type:Research Article
Received:Jun 12, 2013
Accepted:Dec 10, 2013
How to Cite:Ahmadi K, Dadgari F, Safarinejadi Aghdam MR. The most sensitive double-marker method of cardiac isoenzymes of creatinine kinase, troponin I, and myoglobin in different time periods for diagnosing acute myocardial infarction. Ann Mil Health Sci Res. 2014;12(1):e63561. doi:
Abstract
Materials and Methods: This was an observational-analytic research on a diagnostic test conducted on 256 patients who had referred to the emergency department with chest pain from 4 to 24 hours before their referral. They were sorted equally into two groups of 4-14 hours and 15-24 hours from onset of pain, each group including 128 patients.
Results: In the first time period, the combination of troponin and myoglobin had the highest sensitivity (sensitivity = 97.3%, specificity = 98.1%), whereas the combination of double-marker and troponin proved the most sensitive (sensitivity = 100%, specificity = 96.3%).
Conclusion: The double-marker combination of troponin and myoglobin is more appropriate for the first time period (i.e. during the first 24 hours from the onset of chest pain),while it would be more helpful to use the combination of troponin during the second period of time.
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Copyright
© 2014, Annals of Military and Health Sciences Research. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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