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Annals of Military and Health Sciences Research
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Fullerene effect on chemical properties of antihypertensive clonidine in water phase
Author(s):
1Department of Chemistry, Iran
2Department of Chemistry, Andorra
*Corresponding Author: Corresponding author: Roya Ahmadi, Department of Chemistry, Iran Email: [email protected]
Published online:Jan 22, 2014
Article type:Research Article
Received:Sep 24, 2013
Accepted:Dec 18, 2013
How to Cite:Ahmadi R, Pirahan-Foroush M. Fullerene effect on chemical properties of antihypertensive clonidine in water phase. Ann Mil Health Sci Res. 2014;12(1):e63660. doi:
Abstract
Materials and Methods: This study was carried out using computerized calculations of Gaussian program in Becke 3-parameters Lee-Yang-Parr (B3lyp/6-31g level in water on clonidine drug and its fullerene connected form. Impact of fullerene on an anti-blood pressure medicine known as clonidine was analyzed as changes in some properties including energetic levels, stability, highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels, chemical hardness, and electrophilicity properties.
Results: Clonidine lowers blood pressure by decreasing the levels of certain chemicals in blood. This allows blood vessels to relax and the heart to beat more slowly and easily. Results indicated that combining medicine and C60 considerably decreases the energy level and increases the bipolar momentum. Therefore, solubility and reacting ability of the medicine increases in
solution phase of the water.
Conclusion: Totally, combining fullerene structure to an anti-blood pressure medicine, like clonidine, as a nano-carrier enhances the reaction ability of the medicine and it gains more solubility properties in the human body.
References
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© 2014, Annals of Military and Health Sciences Research. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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