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Outline
Side Effects of Sustained-Release Vaginal Suppository Progesterone in Pregnant Women: Gestational Diabetes Mellitus
Authors
1Researcher, Department of obstetrics and gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Andorra
2Department of obstetrics and gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Andorra
3- Researcher, Department of obstetrics and gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Andorra
*Corresponding Author: Corresponding author: soraya saleh gargari, Department of obstetrics and gynecology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Andorra Email: soraya_saleh2000@yahoo.co.uk
Published online:Dec 02, 2013
Article type:Research Article
Received:Aug 24, 2013
Accepted:Nov 17, 2013
How to Cite:Kheyri N, Anbarlooi M, saleh gargari S, Sarfjoo FS. Side Effects of Sustained-Release Vaginal Suppository Progesterone in Pregnant Women: Gestational Diabetes Mellitus. Ann Mil Health Sci Res. 2013;11(4):e64614. doi:
Abstract
Background: Evaluation of the potential impact of vaginal progesterone on both mother and fetus is necessary before expanding the indication of this drug especially throughout pregnancy. To evaluate the potential impact of vaginal progesterone on both mother and fetus. Materials and Methods: This case-control study was designed to collect data on the potential gestational diabetes mellitus complication associated with progesterone use comparing maternal and neonatal outcomes between 245pregnant women receiving vaginal suppository of Cyclogest (200mg) and 808controls without progesterone. Results: The incidence of gestational diabetes was 9.8% and 5.2% in case and control groups, respectively (p=0.039). According to linear regression analysis, there was a direct association between duration of progesterone usage and impairment of glucose tolerance test in group of cases (r=0.43; p=0.002). Conclusions: The use of progesterone for the prevention of recurrent preterm delivery could associate with an increased risk of developing gestational diabetes.
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Copyright
© 2013, Annals of Military and Health Sciences Research. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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