Archives of Clinical Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center, SBUMS
Authors
Congenital cytomegalovirus (CMV) infection affects nearly 1% of live births in the United States. Ten percent of these infants have symptoms at birth and another 10 to 15% develop hearing loss or developmental problems. The aim of this study was to compare CMV infection (IgM and IgG) rate in infants suspected for intrauterine infectionwith the control group.
A case-control study was performed in the Pediatrics Department of Hazrat Rasool Akram Hospital in Tehran. The study population included 74 suspected cases of intrauterine infection (mean age, 4.73.7 months) and 65 normal healthy controls (mean age, 5.33.1 months). We compared serum CMV antibodies (IgM, IgG) with ELISA kits.
Acute and previous immunity to CMV (IgM and IgG) was found in 41.9% (31/74) and 74% (54/74) of cases, respectively. These figures were 6.2% (4/65) and 95.4% (62/65) in controls, respectively. Acute infection (CMV-IgM) was more common among cases (p<0.0001), but previous immunity (CMV-IgG) was more prevalent among controls (p<0.001).
We concluded that CMV is the most common cause of intrauterine infection in infants aged less than 6 months as compared to the healthy ones. We prefer, at least in our country, to consider seropositive (CMV-IgM) infants suspected of intrauterine infection (less than 6 months) as congenital form. To arrest the natural progression of congenital CMV, we recommend prolonged course of oral analogues of ganciclovir for children with symptomatic congenital CMV.
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
noorbakhsh S, Farhadi M, Tabatabaei A. Cytomegalovirus, a Common Cause of Intrauterine Infection: A Case - Control Study in Tehran, Iran. J Compr Ped. 2010;2(1):e93759. doi:
Karimi A, Manaberi M, Azimi L, Taslimi Taleghani N, Shirvani F, et al. Incidence and Prognosis of Congenital Cytomegalovirus Infection, a Retrospective Single-Center Experience, Tehran, Iran. Arch Pediatr Infect Dis. 2023;11(4):e135767. doi: https://doi.org/10.5812/apid-135767
Lakzayi E, Fozouni L, Pordeli H. A Seromolecular Study on the Prevalence of Cytomegalovirus in Pregnant Women Living in Golestan Province, Iran. Shiraz E-Med J. 2020;21(7):e96238. doi: https://doi.org/10.5812/semj.96238
Farshidi F, Abedi G, Moosazadeh M, Afshari M. Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis. Int J Cancer Manag. 2017;10(1):e3704. doi: https://doi.org/10.17795/ijcp-3704
Yang L, Qiu A, Wang J, Pan Z. Comparative Effects of Valganciclovir and Ganciclovir on the Congenital Cytomegalovirus Infection and Hearing Loss: A Randomized Controlled Trial. Inn J Pediatr. 2021;32(1):e118874. doi: https://doi.org/10.5812/ijp.118874
More by these authors
Last Update: 1 month ago
Last Update: 1 month ago
Last Update: 1 month ago
Last Update: 1 day ago