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Archives of Clinical Infectious Diseases

Infectious Diseases and Tropical Medicine Research Center, SBUMS

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Rabies Neutralizing Antibody Level in Immunosuppressed Patients After Receive of Rabies Post-Exposure Prophylaxis

Author(s):
Vida FallahianVida Fallahian,*, Ali EslamifarAli Eslamifar3, Mohammad Amin FayazMohammad Amin Fayaz4, Parisa MashayekhiParisa Mashayekhi2, Peyvand BiglariPeyvand Biglari1
3Department of Clinical Research, Pasteur Institute of Iran, Tehran, IR Iran
4Student of Veterinary Faculty of Tehran University, Tehran, IR Iran
2Prevention and Treatment of Rabies Center, Department of Vaccination, Pasteur Institute of Iran, Tehran, IR Iran
1WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, IR Iran
Archives of Clinical Infectious Diseases:Vol. 6, issue 3; 124-7
Published online:Jul 31, 2011
Article type:Brief Report
How to Cite:Fallahian V, Eslamifar A, Fayaz MA, Mashayekhi P, Biglari P. Rabies Neutralizing Antibody Level in Immunosuppressed Patients After Receive of Rabies Post-Exposure Prophylaxis. Arch Clin Infect Dis. 2011;6(3):. doi:

Abstract

Introduction:

Rabies is a fatal disease and has a threatening risk for the public health. Immunosuppression is related to a wide variety of diseases. It is recommended that immunosuppressed patients receive the full post-exposure vaccination, concerning that the immune response may be inadequate. The aim of this study is to determine the level of rabies neutralizing antibody in immunosuppressed patients after receiving rabies post-exposure prophylaxis. Consequently we assess the efficiency of antibody level in immunosuppressed patients admitted at Pasteur Institute of Iran.

Results:

Twenty two cases were evaluated. The Immunosuppressed state was related to cancer (in 8 cases), 4 cases of hematologic disorders, 6 cases of autoimmune disease, and 4 cases of chronic renal failure or kidney transplant. Mean age of 46.45 21.5 year. All cases received HRIG serum (human rabies immunoglobulin) plus PVRV (Purified Vero cell rabies vaccine). The level of rabies neutralizing antibody was checked two weeks after the last dose of vaccine. Mean level of rabies neutralizing antibody was 12.07 6.72 IU/ml. All cases achieved minimum protective level of antibody which is ? 0.5 IU/ml. The amount of the antibody level had no relation to age or kind of immunosuppressive disease of patients.

Conclusion:

It is recommended that Rabies-exposed immunosuppressed patients receive rabies post exposure prophylaxes. We have to be cautious about the cases who have not achieved the appropriate level of rabies antibody.

Keywords
Post-exposure rabies prophylaxis
Immunosuppressed patients
Rabies neutralizing antibody

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