Archives of Clinical Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center, SBUMS
Authors
Prior investigators demonstrated Helicobacter pylori as a risk factor of liver diseases. In this study association between H. pylori and hepatocellular carcinoma was investigated.
Totally, 59 specimens of liver were collected from two health care centers affiliated to Shahid Beheshti University of Medical Sciences, including 22 specimens of hepatocellular carcinoma, 18 specimens of cirrhosis and 19 normal specimens of liver. Polymerase chain reaction was used to determine the presence of H. pylori in liver samples using H. pylori gene-specific primers.
16srRNA of Helicobacter genus were found in 31.8% of hepatocellular carcinoma and 16.7% of cirrhotic specimens, however, we could not find this gene in normal samples. Meanwhile, the presence of ureC and cagA genes specific for H. pylori were investigated in positive specimens to confirm the H. pylori infection, however, these genes
were not detected.
Helicobacter infection exists in liver of patients with hepatocellular carcinoma. However, further studies are necessary to confirm this association.
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Eslami G, Taheri S, Baseri N, Montazeri SA, Shakeri A, et al. Prevalence of Helicobacter pylori and Determination of Antibiotic Resistance in Patients with Gastritis Referred to Shahid Beheshti University of Medical Sciences Hospitals in Tehran Between 2010 and 2011. Arch Clin Infect Dis. 2012;8(1):18-22. doi: https://doi.org/10.5812/archcid.16031
Samareh-Fekri M, Hashemi Bajgani SM, Shafahi A, Asadi-Zarandi M, Mollaie H, et al. Detection of Helicobacter pylori in the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR. Jundishapur J Microbiol. 2016;9(11):e32144. doi: https://doi.org/10.5812/jjm.32144
Farshad S, Japoni A, Alborzi A, Zarenezhad M, Ranjbar R. Changing Prevalence of Helicobacter Pylori in South of Iran. Arch Clin Infect Dis. 2010;5(2):. doi:
Niknam R, Fattahi MR, Sepehrimanesh M, Safarpour A. Prevalence of Helicobacter pylori in Southern Part of Iran. Jundishapur J Microbiol. 2018;11(6):e62379. doi: https://doi.org/10.5812/jjm.62379
Modaresi Esfeh J, Ostadrahimi A, Somi MH, Roshangar L, Pourghassem Gargari B, et al. The relationship between helicobacter pylori infection and dietary habits. J Kermanshah Univ Med Sci. 2011;15(3):e79357. doi:
Last Update: 1 month ago
Last Update: 1 month ago
Last Update: 1 month ago
Last Update: 1 day ago
Last Update: 2 days ago
Last Update: 5 days ago
