Archives of Clinical Infectious Diseases
Chronic sinusitis is one of the most common medical problems affecting 30 million people in USA annually. In the present study, we compared the efficacy and safety of clarithromycin XL and co-amoxiclav on clinical and CT scan findings of patients suffering from chronic sinusitis.
In this clinical trial, a total of 59 subjects (37 males and 22 females, mean age 28 years) with clinical symptoms and CT scan findings of chronic sinusitis were assigned randomly in two groups and treated with clarithromycin XL or coamoxiclav.
Clinical success rates were similar at the end of therapy period, however, subjects receiving clarithromycin XL showed better CT scan findings when compared with co-amoxiclav-treated subjects (53% versus 29%). Gastrointestinal discomfort was the most frequent treatmentrelated adverse effects in both groups (NS).
Results revealed that clarithromycin XL and co-amoxiclav have similar efficacy when considered for treatment of chronic sinusitis.
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Rastegar Lari A, Ghaffariyeh A, Etesam N, Mostafavi H, Alaghehbandan R. A Randomized Controlled Trial of 5-Day Regimen of Azithromycin and a 10-Day Regimen of Co-amoxiclav for Treatment of Acute Sinusitis. Arch Clin Infect Dis. 2010;5(3):. doi:
Maneshi A, Modaresi MR, Khalili H, Shojae L, Faghihi T. Nebulized Azithromycin Versus Oral Azithromycin as Anti-Inflammatory Therapy in Children with Cystic Fibrosis: A Prospective Randomized Open-Label Trial. Inn J Pediatr. 2019;29(6):e96977. doi: https://doi.org/10.5812/ijp.96977
Esmaeili-Dooki MR, Shirdel H, Hajiahmadi M. Eradication of Helicobacter pylori in Children by Triple Therapy Regimens of Amoxicillin, Omeprazole, and Clarithromycin or Azithromycin. Inn J Pediatr. 2015;25(6):e2360. doi: https://doi.org/10.5812/ijp.2360
Aslani A, Fathi A. Formulation and Evaluation of Co-Amoxiclav 228 and 312 mg Dispersible Tablets. J Rep Pharm Sci. 2016;5(1):e147656. doi:
Foroutan SM, Zarghi A, Shafaati A, Madadian B, Abolfathi F. Rapid High Performance Liquid Chromatographic Method for Determination of Clarithromycin in Human Plasma Using Amperometric Detection: Application in Pharmacokinetic and Bioequivalence Studies. Iran J Pharm Res. 2013;12(Suppl):e125604. doi: https://doi.org/10.22037/ijpr.2013.1273
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):
