Archives of Clinical Infectious Diseases
Infectious Diseases and Tropical Medicine Research Center, SBUMS
Authors
Staphylococcus aureus is one of the most important causes of nosocomial infections and most clinical isolates are multidrug resistant. Resistance to ?-lactam antibiotics is most often due to bacterial ?-lactamase production. Characterization of ?-lactamases is important for choosing appropriate antibiotic therapy.
Thirty methicillin resistant Staphylococcus aureus (MRSA) were identified by standard biochemical methods. Antibacterial susceptibility to 9 ?-lactam antibiotics was determined. ?-lactamase production was shown in all isolates using the colony iodometric test and nitrocefin discs. ?-lactamase typing was carried out by measuring the relative substrate hydrolysis rates.
The MRSA isolates were resistant to the majority of ?-lactam antibiotics. The results showed that 90% of the isolates displayed type A substrate hydrolysis profile of ?-lactamase.
The alarming high level of resistance to ?-lactam antibiotics including methicillin and 3rd generation ?-lactams show the need for extensive studies on alternative treatment protocols and use of new drugs
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Armin S, Fallah F, Navidinia M, Vosoghian S. Prevalence of blaOXA-1 and blaDHA-1 AmpC β-Lactamase-Producing and Methicillin-Resistant Staphylococcus aureus in Iran. Arch Pediatr Infect Dis. 2017;5(4):e36778. doi: https://doi.org/10.5812/pedinfect.36778
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