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39 resultsUpdated October 23, 2026
1

Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease

Mitochondrion 53 (2020)

Christina A. Castellani; Ryan J. Longchamps; Jing Sun; Eliseo Güallar; Dan E. Arking

2

Human mitochondrial DNA is extensively methylated in a non-CpG context

Nucleic Acids Research 47(19) (2019)

Vibha Patil; Cyrille Cuenin; Felicia Fei‐Lei Chung; Jesús Rafael Rodríguez‐Aguilera; Nora Fernández‐Jiménez; Irati Romero Garmendia; José Ramón Bilbao; Vincent Cahais; Joseph A. Rothwell; Zdenko Herceg

3

Metabolic Dysfunction‐Associated Steatotic Liver Disease ( MASLD ): Mechanisms, Clinical Implications and Therapeutic Advances

Endocrinology Diabetes & Metabolism 8(6) (2025)

Dalia M. Miller; Kiana F. McCauley; Kimberly J. Dunham‐Snary

4

A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet

Molecules 27(3) (2022)

Mohammed Abdullah Alshawsh; Abdulsamad Alsalahi; Salah Abdalrazak Alshehade; Sultan Ayesh Mohammed Saghir; Ahmad Faheem Ahmeda; Raghdaa Hamdan Al Zarzour; Ayman Moawad Mahmoud

5

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology 77(4) (2022)

Dimitri Loureiro; Issam Tout; Stéphanie Narguet; Cheikh Mohamed Bed; Morgane Roinard; Ahmad Sleiman; Nathalie Boyer; Nathalie Pons‐Kerjean; Corinne Castelnau; Nathalie Giuly; Dorothy Tonui; Vassili Soumelis; Jamel El Benna; Patrick Soussan; Richard Moreau; Valérie Paradis; Abdellah Mansouri; Tarik Asselah

6

Precise targeting of transcriptional co-activators YAP/TAZ annihilates chemoresistant brCSCs by alteration of their mitochondrial homeostasis

Signal Transduction and Targeted Therapy 10(1) (2025)

Priyanka Dey Talukdar; Kunal Pramanik; Priya Gatti; Pritha Mukherjee; Deepshikha Ghosh; Himansu Roy; Marc Germain; Urmi Chatterji

8

Emerging PFAS Exposure Is More Potent in Altering Childhood Lipid Levels Mediated by Mitochondrial DNA Copy Number

Environmental Science & Technology 59(5) (2025)

Peiwei Xu; Min Nian; Jie Xiang; Xinhan Zhang; Ping Cheng; Dandan Xu; Yuan Chen; Xiaofeng Wang; Zhijian Chen; Xiaoming Lou; Mingliang Fang

9

Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

Mediators of Inflammation 2019 (2019)

Lili Yu; Yànhuá Lǐ; Cancan Du; Weidong Zhao; Hanxiao Zhang; Yun Yang; Aiping Sun; Xiangfeng Song; Zhiwei Feng

10

Emerging roles of Toll-like receptor 9 in cardiometabolic disorders

Inflammation and Regeneration 40(1) (2020)

Sachiko Nishimoto; Daiju Fukuda; Masataka Sata

11

A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Cells 8(10) (2019)

Afshan N. Malik; Inês C. M. Simões; Hannah S. Rosa; Safa Z. Khan; Agnieszka Karkucińska‐Więckowska; Mariusz Roman Wieckowski

12

Testosterone Deficiency Caused by Castration Modulates Mitochondrial Biogenesis Through the AR/PGC1α/TFAM Pathway

Frontiers in Genetics 10 (2019)

Can Liu; Jideng Ma; Jinwei Zhang; Han Zhao; Yan Wu Zhu; Jing Qi; Lingyan Liu; Li Zhu; Yanzhi Jiang; Guoqing Tang; Xuewei Li; Mingzhou Li

13

A novel HSF1 activator ameliorates non‐alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation

British Journal of Pharmacology 179(7) (2021)

Yong Rao; Chan Li; Yu‐Tao Hu; Yao‐Hao Xu; Bingbing Song; Shi‐Yao Guo; Zhi Jiang; Dandan Zhao; Shuo-Bin Chen; Jia‐Heng Tan; Shi‐Liang Huang; Qingjiang Li; Xiaojun Wang; Yingjun Zhang; Ji‐Ming Ye; Zhi‐Shu Huang

14

Mitochondrial DNA methylation in metabolic associated fatty liver disease

Frontiers in Nutrition 10 (2023)

Archibold Mposhi; Fabián Cortés-Mancera; Janette Heegsma; Vincent E. de Meijer; Bart van de Sluis; Svenja Sydor; Lars P. Bechmann; Claudia Theys; Peter De Rijk; Tim De Pooter; Wim Vanden Berghe; İkbal Agah İnce; Klaas Nico Faber; Marianne G. Rots

15

Advances in Noninvasive Biomarkers for Nonalcoholic Fatty Liver Disease

Metabolites 13(11) (2023)

Georgiana-Emmanuela Gîlcă-Blanariu; Daniela Simona Budur; Dana Mitrică; Elena Gologan; Oana Timofte; Gheorghe Gh Bălan; VASILE-ANDREI OLTEANU; Gabriela Ștefănescu

16

Investigation of FGF21 mRNA levels and relative mitochondrial DNA copy number levels and their relation in nonalcoholic fatty liver disease: a case-control study

Frontiers in Molecular Biosciences 10 (2023)

Massoud Houshmand; Vahide Zeinali; Amirhossein Hosseini; Atena Seifi; Bardia Danaei; Sharareh Kamfar

17

Peripheral blood mononuclear cell mitochondrial copy number and adenosine triphosphate inhibition test in NAFLD

Frontiers in Endocrinology 13 (2022)

A-Hyeon Lee; Ju‐Hee Oh; Hyun Sung Kim; Jeong‐Hun Shin; Eileen Laureal Yoon; Dae Won Jun

18

Mitochondrial DNA copy number in Hepatitis C virus-related chronic liver disease: impact of direct-acting antiviral therapy

Scientific Reports 13(1) (2023)

Amany Saleh Elyamany; Rasha Abdelmawla Ghazala; Omnia Fayed; Yasmin Hamed; Assem El-Shendidi

21

Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice

Biochemical and Biophysical Research Communications 527(2) (2020)

Yoshihisa Arao; Hirokazu Kawai; Kenya Kamimura; Takamasa Kobayashi; Oki Nakano; Manabu Hayatsu; Tatsuo Ushiki; Shuji Terai

22

Leukocyte mitochondrial DNA copy number as a potential biomarker indicating poor outcome in biliary atresia and its association with oxidative DNA damage and telomere length

Mitochondrion 47 (2019)

Wanvisa Udomsinprasert; Yong Poovorawan; Voranush Chongsrisawat; Paisarn Vejchapipat; Jiraphun Jittikoon; Sittisak Honsawek

23

Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study

Diabetologia 65(10) (2022)

Wenyi Wang; Jiao Min Luo; Ko Willems van Dijk; Sara Hägg; Felix Graßmann; Leen M. ‘t Hart; Diana van Heemst; Raymond Noordam

24

The distinct spatiotemporal distribution and effect of feed restriction on mtDNA copy number in broilers

Scientific Reports 10(1) (2020)

Xiangli Zhang; Ting Wang; Jiefei Ji; Huanjie Wang; Xinghao Zhu; Pengfei Du; Yao Zhu; Yanqun Huang; Wen Chen

25

The Non-Invasive Assessment of Circulating D-Loop and mt-ccf Levels Opens an Intriguing Spyhole into Novel Approaches for the Tricky Diagnosis of NASH

International Journal of Molecular Sciences 24(3) (2023)

Erika Paolini; Miriam Longo; Alberto Corsini; Paola Dongiovanni

26

Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients

BioMed Research International 2018 (2018)

Po-Jung Wu; Jin‐Bor Chen; Wen‐Chin Lee; Hwee‐Yeong Ng; Shu-Ching Lien; Pei-Ying Tsai; Chien‐Hsing Wu; Chien‐Te Lee; Terry Ting‐Yu Chiou

27

Association Between Leukocyte Mitochondrial DNA Copy Number and Non-alcoholic Fatty Liver Disease in a Chinese Population Is Mediated by 8-Oxo-2′-Deoxyguanosine

Frontiers in Medicine 7 (2020)

Chifa Ma; Yiwen Liu; Shuli He; Jingbo Zeng; Pingping Li; Chunxiao Ma; Fan Ping; Huabing Zhang; Lingling Xu; Wei Li; Yuxiu Li

28

Hepatic oxidative injury: role of mitochondrial dysfunction in necrotizing enterocolitis

Pediatric Surgery International 37(3) (2021)

Edoardo Bindi; Mashriq Alganabi; George Biouss; Jia Liu; Bo Li; Hiromu Miyake; Rossella Angotti; Agostino Pierro

29

Expanding role of deoxyribonucleic acid-sensing mechanism in the development of lifestyle-related diseases

Frontiers in Cardiovascular Medicine 9 (2022)

Sachiko Nishimoto; Masataka Sata; Daiju Fukuda

30

Regulation of Mitochondrial Function by Natural Products for the Treatment of Metabolic Associated Fatty Liver Disease

Canadian Journal of Gastroenterology and Hepatology 2021(1) (2021)

Tingting Shi; Liping Yu; Rangxiao Zhuang; Jianjun Xi; Ruoyu He; Yidan Shao; Jinsong Huang; Shourong Liu; Xingxin Yang

31

Restoring Mitochondrial Homeostasis: Therapeutic Strategies for Metabolic Dysfunction-Associated Fatty Liver Disease

International Journal of Molecular Sciences 27(6) (2026)

José S. Morgado; Ivo F. Machado; Anabela Pinto Rolo; Carlos M. Palmeira

32

Natural Product Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease: Targeted Mitochondrial Quality Control

Drug Design Development and Therapy Volume 20 (2026)

Jing Liu; Fuxing Li; Qianru Zeng; Wenxiao Hu; Le Yang; Shengping Luo; Fang Lv; Dingxiang Li; Yihui Deng

33

Analysis of Mitochondrial 4977-bp Deletion and D-Loop Variation in Iranian Non-Alcoholic Fatty Liver Disease Patients

Hepatitis Monthly In Press(In Press) (2019)

Sharareh Kamfar; Seyed Moayed Alavian; Kambiz Hasrak; Massoud Houshmand; Bahram Seifizarei; Alireza Khalaj; Forough Homaunpur; Massoud Saidijam

34

Toll-like receptor gene 7 and gene 9 in MASLD

The Egyptian Journal of Internal Medicine 38(1) (2026)

Amal Ahmed; Marwa Ali Haseeb Tahoon; Lamees Ahmed Samy; M A Selim; Sofia Ashraf; Amira Yones; Wafaa Abdelhamid; Reem Abdelghafour; Randa Ibrahim; Ahmed Ramadan Mohamed; Mohamed El‐Kassas; Reem Ezzat Mahdy

36

Mitochondrial DNA copy number in diabetic kidney disease: translational prospects and challenges

Archives of Physiology and Biochemistry (2026)

Lixia Lu; Yongtong Cao; Liang Ma; Xiaomu Kong

37

Altered Mitochondrial Base Excision Repair and Mitochondrial DNA Instability in Peripheral Leukocytes of Patients with MASLD

Cells 15(15) (2026)

Sylwia Ziółkowska; Marcin Kosmalski; Bianka Świderska; Agnieszka Fabijańska; Kinga Jarmusz; Magdalena Ejsmont; Adam Marek Wróblewski; Janusz Szemraj; Tadeusz Pietras; Aleksandra Jabłkowska; Piotr Lech Czarny