Prevalence and Clinical Significance of Hepatitis B Basal Core Promoter and Precore Gene Mutations in Southern Iranian Patients

Seyed Taghavi; Manouchehr Tabibi; Ahad Eshraghian; Hossein Keyvani; Hamed Eshraghian

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Prevalence and Clinical Significance of Hepatitis B Basal Core Promoter and Precore Gene Mutations in Southern Iranian Patients

Author(s):

Seyed Alireza Taghavi¹,

Manouchehr Tabibi¹,

Ahad Eshraghian^2,*,

Hossein Keyvani³,

Hamed Eshraghian¹

1Gastroenterohepatology Research Center, Shiraz University of Medical Science, Fars, IR Iran

2Gastroenterohepatology Research Center, Shiraz University of Medical Science, [email protected], Fars, IR Iran

3Microbiology department, Iran University of medical science, Tehran, IR Iran

Hepatitis Monthly:Vol. 10, issue 4; 294-297

Published online:Dec 31, 2010

Article type:Research Article

Received:Jan 03, 2010

Accepted:May 07, 2010

How to Cite:Taghavi S, Tabibi M, Eshraghian A, Keyvani H, Eshraghian H. Prevalence and Clinical Significance of Hepatitis B Basal Core Promoter and Precore Gene Mutations in Southern Iranian Patients. Hepat Mon. 2010;10(4):. doi:

Abstract

Background and Aims: To investigate the prevalence and pattern of PC and BCP mutations and their clinical significance in patients with genotype D chronic hepatitis B infection in the Fars province of southern Iran.
Materials and Methods: From January 2007 to March 2008, we evaluated 44 patients with chronic hepatitis B infection who were referred to our hepatology clinics affiliated with the Shiraz University of Medical Science. All Patients were HBeAg Negative and HBeAb positive. Basal core promoter and precore mutations in these patients were evaluated with clinical phenotype and laboratory tests.
Results: The mean age of the patients was 37.21 ± 10.54 years. Twenty-seven patients (61.4%) had no mutations, whereas 17 patients (38.6%) had mutations in the precore or basal core promoter regions or both. The mean serum ALT level in mutation-free patients was 59.74 ± 55.86 IUL, whereas patients with PC and BCP mutations had a mean serum ALT level of 71.35 ± 59.49 IUL. The mean serum AST level in patients with mutations was higher than for patients without mutations (59.53 ± 41.35 IUL vs. 40.65 ± 25.21 IUL, respectively). There was no statistically significant difference between the mutation and mutation-free groups in terms of age, sex, and liver enzyme levels (P > 0.05). Fourteen of the 44 patients (31.8%) had mutations in the precore region (G 1896A). 17 patients (38.6%) had mutations in basal core promoter region.
Conclusion: This study revealed a high prevalence of precore and basal core promoter mutations in southern Iran. Although no statistically significant difference was noted in liver enzymes, patients with mutations had higher liver enzymes in comparison with mutation-free patients.

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Zhand S, Karami C, Hosseinzadeh Adli A, Tabarraei A, Khodabakhshi B, et al. Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients. Jundishapur J Microbiol. 2015;8(2):e17126. doi: https://doi.org/10.5812/jjm.17126

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Hossein Poustchi,

Ashraf Mohamadkhani,

Aezam Katoonizadeh,

Abdolvahab Moradi,

Gholamreza Roshandel

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Besharat S, Poustchi H, Mohamadkhani A, Katoonizadeh A, Moradi A, et al. Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran. Hepat Mon. 2015;15(2):e23875. doi: https://doi.org/10.5812/hepatmon.23875

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Ayari R, Lakhoua-Gorgi Y, Bouslama L, Safar I, Kchouk FH, et al. Investigation of DNA Sequence in the Basal Core Promoter, Precore, and Core Regions of Hepatitis B Virus from Tunisia Shows a Shift in Genotype Prevalence. Hepat Mon. 2012;12(11):6191. doi: https://doi.org/10.5812/hepatmon.6191

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Author(s):

Seyed Taghavi:[PubMed][Scholar]
Manouchehr Tabibi:[PubMed][Scholar]
Ahad Eshraghian:[PubMed][Scholar]
Hossein Keyvani:[PubMed][Scholar]
Hamed Eshraghian:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Prevalence and Clinical Significance of Hepatitis B Basal Core Promoter and Precore Gene Mutations in Southern Iranian Patients

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