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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Induced HBs antigenemia in healthy adults after immunization with two different hepatitis B recombinant vaccines
Authors
1Infectious Disease Ward, Birjand University of Medical Sciences, Khorasan-e-Jonoubi, IRIran
2Birjand University of Medical Sciences, Khorasan-e-Jonoubi, IR Iran
3Birjand University of Medical Sciences, mhnamaei@hotmail.com, Khorasan-e-Jonoubi, IR Iran
*Corresponding Author: Birjand University of Medical Sciences, mhnamaei@hotmail.com, Khorasan-e-Jonoubi, IR Iran. Tel: +98-9151612148. Fax: +98-9151612148. Email: mhnamaei@hotmail.com
Published online:Dec 31, 2010
Article type:Research Article
Received:Jan 02, 2010
Accepted:Sep 10, 2010
How to Cite:Ziaee M, Saadatjoo A, Mohamadpour M, Namaei M. Induced HBs antigenemia in healthy adults after immunization with two different hepatitis B recombinant vaccines. Hepat Mon. 2010;10(4):. doi:
Abstract
Background and Aims: Currently, vaccination is the most effective protective tool against hepatitis B virus infection. Some studies have shown that positive results for a hepatitis B virus surface antigen (HBsAg) test may be seen after vaccination. The aim of this study was to compare the incidence of positive HBsAg results after vaccination with two different hepatitis B recombinant vaccines.
Materials and Methods: In this clinical trial study, 62 healthy adult volunteers were randomly assigned to receive either the Engerix-B or the Hepavax-Gene hepatitis B recombinant vaccine. Blood samples were drawn 1, 3, and 5 days after vaccination and were tested for HBsAg using two different ELISA kits (Behring and Mega).
Results: HBsAg was positive in 5, 3, and 2 participants of the Engerix-B group in the 1st, 3rd, and 5th days after vaccination, respectively, using the Behring ELISA kit; the test was positive in only one subject in the Hepavax-Gene group, on the 5th day after vaccination. No positive result was seen in any groups when the Mega ELISA kit was used to test the specimens.
Conclusions: Our results showed transient HBsAg antigenemia after vaccination against hepatitis B. This condition depends on the type of vaccine and the HBsAg diagnostic test.
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Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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