Seroprevalence of Delta Hepatitis in Patients with Chronic Hepatitis B and its Clinical Impact in Khuzestan Province, Southwest Iran

Seyed Hashemi; Fariba Jalali; Eskandar Hajiani

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

Home

Instructions

APC

Authors Guide Submit Manuscript

Outlines

Abstract
Copyright

Seroprevalence of Delta Hepatitis in Patients with Chronic Hepatitis B and its Clinical Impact in Khuzestan Province, Southwest Iran

Author(s):

Seyed Hashemi,

Fariba Jalali,

Eskandar Hajiani^1,*

1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Emam Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Hepatitis Monthly:Vol. 9, issue 4; 287-292

Published online:Dec 31, 2009

Article type:Research Article

Received:Nov 06, 2008

Accepted:Jun 01, 2009

How to Cite:Hashemi S, Jalali F, Hajiani E. Seroprevalence of Delta Hepatitis in Patients with Chronic Hepatitis B and its Clinical Impact in Khuzestan Province, Southwest Iran. Hepat Mon. 2009;9(4):. doi:

Abstract

Background & Aims: Hepatitis B virus (HBV) and hepatitis D virus (HDV) infections are major health problems in Iran. Preliminary reports indicate that HDV infection, a satellite virus of HBV, exists in this area. However, its prevalence in patients with different types of liver diseases has not been studied in detail. This study was carried out to determine the seroprevalence of HDV among individuals who tested positive for hepatitis B surface antigen (HBsAg) in a southwestern province of Iran.

Methods: In this cross-sectional study a total of 1,725 consecutive patients with HBV liver diseases attending the Ahwaz JundiShapur University Hospitals (AJSUH) and Hepatitis Clinics from 2002 to 2008 were included. We performed tests for HBV and HDV serum markers, using commercially available enzyme-linked immunosorbent assay kits. Patients were split into two groups according to their HDV antibody (anti-HDV) status (HDV positive or negative). The collected data were coded, and the statistical analyses were conducted.

Results: The mean age of the patients was 37 ± 13/8 years. There were 1,157 males and 568 females. Of the 1,725 patients with HBV liver disease, 150 were found to be reactive for anti-delta antibodies, yielding an overall HDV seroprevalence of 11.5%. Anti-HDV was found in 3.59% of patients with inactive chronic hepatitis, 45.5% of patients with chronic active hepatitis, and 43.2% of cirrhotic and hepatocellular carcinoma patients (P < 0.001). A higher proportion of individuals testing positive for antibodies to HDV were observed among males (72%) than among females (28%). The patients without HDV infection were younger than anti-HDV-positive/HBsAg-positive patients (P < 0.01).

Conclusions: HDV infection was common in patients with HBV in our community. All HBV patients should be screened for HDV infection. The results indicate that HDV co-infection was related to the severity of the liver disease. More studies designed to elucidate HDV's epidemiology are needed.

Keywords

Fulltext

Full text is available in PDF

Sero-Prevalence of Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Positive Patients in Mashhad, Northeastern Iran

Sanaz Ahmadi Ghezeldasht,

Mohammad Reza Hedayati-Moghaddam,

Arman Mosavat,

Mohammad Mehdi Akbarin

Ahmadi Ghezeldasht S, Hedayati-Moghaddam MR, Mosavat A, Akbarin MM. Sero-Prevalence of Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Positive Patients in Mashhad, Northeastern Iran. Mod Care J. 2019;16(3):e93956. doi: https://doi.org/10.5812/modernc.93956

25

Aug

2013

Prevalence of Hepatitis D Virus Infection Among Patients With Chronic Hepatitis B Attending Birjand Hepatitis Clinic (East of Iran) in 2012

Masood Ziaee,

Ghodsieh Azarkar

Ziaee M, Azarkar G. Prevalence of Hepatitis D Virus Infection Among Patients With Chronic Hepatitis B Attending Birjand Hepatitis Clinic (East of Iran) in 2012. Hepat Mon. 2013;13(8):e11168. doi: https://doi.org/10.5812/hepatmon.11168

6

May

2017

Prevalence of Hepatitis D Virus Infection and Associated Factors Among HBsAg-Positive Patients in Birjand, Iran, 2012 - 2014

Gholamreza Sharifzadeh,

Mohammad Hasan Namaei,

Azadeh Ebrahimzadeh,

Zohreh Azarkar,

Mohammad Fereidouni,

Bita Bijari

,et al.

Sharifzadeh G, Namaei MH, Ebrahimzadeh A, Azarkar Z, Fereidouni M, et al. Prevalence of Hepatitis D Virus Infection and Associated Factors Among HBsAg-Positive Patients in Birjand, Iran, 2012 - 2014. Hepat Mon. 2017;17(5):e42866. doi: https://doi.org/10.5812/hepatmon.42866

31

Dec

2008

Hepatitis D in Chronic Active Hepatitis B: Prevalence, Liver Enzyme Levels and Histopathology- an Epidemiological Study in Shiraz, Southern Iran, 2003-2004

Seyed Alireza Taghavi,

Shabnam Sedighi,

Davood Mehrabani,

Farnaz Khademolhoesseini

Taghavi S, Sedighi S, Mehrabani D, Khademolhoesseini F. Hepatitis D in Chronic Active Hepatitis B: Prevalence, Liver Enzyme Levels and Histopathology- an Epidemiological Study in Shiraz, Southern Iran, 2003-2004. Hepat Mon. 2008;8(4):. doi:

30

Jun

2010

A Study of HDV in HBsAg Positive Patients in Tabriz, Northwestern Iran

S Gltuna,

I Yksel,

O Ba?ar,

O skdar,

Seyfettin Köklü

Gltuna S, Yksel I, Ba?ar O, skdar O, Köklü S. A Study of HDV in HBsAg Positive Patients in Tabriz, Northwestern Iran. Hepat Mon. 2008;8(4):. doi:

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 2 weeks ago
Scopus by Title: 18
Last Update: 2 weeks ago
Scopus by Title (Ref): 18
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 2 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Seyed Hashemi:[PubMed][Scholar]
Fariba Jalali:[PubMed][Scholar]
Eskandar Hajiani:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

Outlines

Seroprevalence of Delta Hepatitis in Patients with Chronic Hepatitis B and its Clinical Impact in Khuzestan Province, Southwest Iran

Abstract

Fulltext

Similar Articles

Sero-Prevalence of Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Positive Patients in Mashhad, Northeastern Iran

Prevalence of Hepatitis D Virus Infection Among Patients With Chronic Hepatitis B Attending Birjand Hepatitis Clinic (East of Iran) in 2012

Prevalence of Hepatitis D Virus Infection and Associated Factors Among HBsAg-Positive Patients in Birjand, Iran, 2012 - 2014

Hepatitis D in Chronic Active Hepatitis B: Prevalence, Liver Enzyme Levels and Histopathology- an Epidemiological Study in Shiraz, Southern Iran, 2003-2004

A Study of HDV in HBsAg Positive Patients in Tabriz, Northwestern Iran

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 days ago