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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Autoantibodies in Hepatitis C Virus-Related Chronic Liver Disease
Authors
1Department of Gastroenterology and Neurology, Kagawa University School of Medicine, thimoto@med.kagawa-u.ac.jp, Japan
2Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Japan
*Corresponding Author: Department of Gastroenterology and Neurology, Kagawa University School of Medicine, thimoto@med.kagawa-u.ac.jp, Japan. Tel: +81 87 891 2156. Fax: +81 87 891 2158. Email: thimoto@med.kagawa-u.ac.jp
Published online:Dec 31, 2008
Article type:Review Article
Received:Jun 16, 2008
Accepted:Sep 28, 2008
How to Cite:Himoto T, Nishioka M. Autoantibodies in Hepatitis C Virus-Related Chronic Liver Disease. Hepat Mon. 2008;8(4):. doi:
Abstract
Persistent hepatitis C virus (HCV) infection evokes autoimmune response including production of autoantibodies and concomitant autoimmune disorders. Numerous types of autoantibodies such as non-organ-specific autoantibodies and liver-specific autoantibodies have been identified in sera of patients with HCV-related chronic liver disease (CLD). The production of these autoantibodies in HCV-related CLD reflects "virus-induced autoimmunity." Molecular mimicry between the HCV polyprotein and self-proteins, and polyclonal B cell activation by chronic HCV infection have been proposed as possible mechanisms for the occurrence of autoantibodies in HCV-related CLD. Some autoantibodies are tightly associated with concurrent autoimmune diseases, and others closely associated with peculiar human leukocyte antigen (HLA) haplotypes. Changes in the titers of autoantibodies during the antiviral treatment may predict the sustained virological response in individuals. In this article, we mainly focus on the interpretations of autoantibodies in HCV-related CLD.
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Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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