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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Adefovir as a Novel Drug for the Treatment of Chronic Hepatitis B in Patients with End-Stage Renal Disease and Kidney Recipients
Authors
1Urology and Nephrology Research Center (UNRC), Shahid Beheshti University, M.C., h_sasan@hotmail.com, IR-Iran
2Urology and Nephrology Research Center (UNRC), Shahid Beheshti University, M.C., IR-Iran
*Corresponding Author: Urology and Nephrology Research Center (UNRC), Shahid Beheshti University, M.C., h_sasan@hotmail.com, IR-Iran. Tel: +98 21 22567222. Fax: +98 21 22567282. Email: h_sasan@hotmail.com
Published online:Jun 30, 2008
Article type:Review Article
Received:Dec 16, 2007
Accepted:May 20, 2008
How to Cite:Hosseini Moghaddam S, Pour E. Adefovir as a Novel Drug for the Treatment of Chronic Hepatitis B in Patients with End-Stage Renal Disease and Kidney Recipients. Hepat Mon. 2008;8(2):. doi:
Abstract
Administration of adefovir dipivoxil (ADV) has been shown to provide an increased rate of hepatitis Be (HBe) seroconversion. It is also effective in the treatment of HIV. Because of its significant nephrotoxicity after 24 weeks of the treatment, this drug is no longer used for management of HIV. However, hepatitis B virus is inhibited with lower doses of ADV. The drug can even be used safely in those with renal impairment. This review provides new aspects of treatment of hepatitis B using ADV, especially in patients with renal dysfunction as well as renal transplant recipients. We showed that ADV can be used as a safe drug in renal transplant recipients.
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Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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