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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Hepatitis B Virus PreS Variant and Hepatocellular Carcinoma
Authors
1Baqiyatallah Research Center for Gastroenterology and Liver Disease (BRCGL), Baqiyatallah University of Medical Sciences, IR-Iran
2Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, jazayerism@sina.tums.ac.ir, IR-Iran
*Corresponding Author: Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, jazayerism@sina.tums.ac.ir, IR-Iran. Tel: +98 21 88950187. Fax: +98 21 88954913. Email: jazayerism@sina.tums.ac.ir
Published online:Jun 30, 2008
Article type:Review Article
Received:Dec 22, 2007
Accepted:May 11, 2008
How to Cite:Goodarzi Z, Jazayeri S. Hepatitis B Virus PreS Variant and Hepatocellular Carcinoma. Hepat Mon. 2008;8(2):. doi:
Abstract
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. HCC is associated with multiple risk factors. Although the association between chronic hepatitis B virus (HBV) infection and HCC is well established, the underlying mechanism of HBV-related hepatocarcinogenesis still remains elusive. Viral proteins such as X protein and the truncated middle S protein have been implicated to be tranactivators. Recently, studies are focused on mutations within the HBV genome that may be associated with HCC. Deletions in the 3' end of preS1 and 5' terminal of preS2 may emerge during the course of chronic HBV infection which may potentially lead to impairment in immune clearance of these variants. The preS mutant proteins are localized in the endoplasmic reticulum (ER) and have been implicated in the induction of ER stress responses. The ER stress response induces a series of signal transduction pathways and oxidative DNA damage. Furthermore, preS2 mutant protein can upregulate cyclin A expression and induce nodular proliferation of hepatocytes. The findings in this review are important to study the correlation between HCC and preS deletion mutants.
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Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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