Hepatitis B Virus PreS Variant and Hepatocellular Carcinoma

Zahra Goodarzi; Seyed Jazayeri

Hepatitis Monthly

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Hepatitis B Virus PreS Variant and Hepatocellular Carcinoma

Author(s):

Zahra Goodarzi¹,

Seyed Mohamad Jazayeri^2,*

1Baqiyatallah Research Center for Gastroenterology and Liver Disease (BRCGL), Baqiyatallah University of Medical Sciences, IR-Iran

2Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, [email protected], IR-Iran

Hepatitis Monthly:Vol. 8, issue 2; 129-133

Published online:Jun 30, 2008

Article type:Review Article

Received:Dec 22, 2007

Accepted:May 11, 2008

How to Cite:Goodarzi Z, Jazayeri S. Hepatitis B Virus PreS Variant and Hepatocellular Carcinoma. Hepat Mon. 2008;8(2):. doi:

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. HCC is associated with multiple risk factors. Although the association between chronic hepatitis B virus (HBV) infection and HCC is well established, the underlying mechanism of HBV-related hepatocarcinogenesis still remains elusive. Viral proteins such as X protein and the truncated middle S protein have been implicated to be tranactivators. Recently, studies are focused on mutations within the HBV genome that may be associated with HCC. Deletions in the 3' end of preS1 and 5' terminal of preS2 may emerge during the course of chronic HBV infection which may potentially lead to impairment in immune clearance of these variants. The preS mutant proteins are localized in the endoplasmic reticulum (ER) and have been implicated in the induction of ER stress responses. The ER stress response induces a series of signal transduction pathways and oxidative DNA damage. Furthermore, preS2 mutant protein can upregulate cyclin A expression and induce nodular proliferation of hepatocytes. The findings in this review are important to study the correlation between HCC and preS deletion mutants.

Keywords

Hepatitis B Virus

PreS

Hepatocellular Carcinoma

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Zahra Goodarzi:[PubMed][Scholar]
Seyed Jazayeri:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Hepatitis B Virus PreS Variant and Hepatocellular Carcinoma

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