Obesity and Air Pollution: Global Risk Factors for Pediatric Non-alcoholic Fatty Liver Disease

Farahnaz Joukar; Sepiedeh Besharati; Hasan Mirpour; Fariborz Mansour Ghanaei

Hepatitis Monthly

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Obesity and Air Pollution: Global Risk Factors for Pediatric Non-alcoholic Fatty Liver Disease

Author(s):

Farahnaz Joukar,

Sepiedeh Besharati,

Hasan Mirpour,

Fariborz Mansour Ghanaei^1,*

1Parinaz Poursafa, Department of Environment and Energy, Science and Research Branch, Islamic Azad University, Tehran, IR Iran. Tel: +98-2144865100 Fax: +98-2144865154,

Hepatitis Monthly:Vol. 11, issue 3; 794-802

Published online:Oct 31, 2011

Article type:Review Article

Received:Jun 12, 2011

Accepted:Jul 25, 2011

How to Cite:Joukar F, Besharati S, Mirpour H, Mansour Ghanaei F. Obesity and Air Pollution: Global Risk Factors for Pediatric Non-alcoholic Fatty Liver Disease.Hepat Mon.2011;11(3):794-802.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is becoming as an important health problem in the pediatric age group. In addition to the well-documented role of obesity on the fatty changes in liver, there is a growing body of evidence about the role of environmental factors, such as smoking and air pollution, in NAFLD. Given that excess body fat and exposure to air pollutants is accompanied by systemic low-grade inflammation, oxidative stress, as well as alterations in insulin/insulin-like growth factor and insulin resistance, all of which are etiological factors related to NAFLD, an escalating trend in the incidence of pediatric NAFLD can be expected in the near future. This review focuses on the current knowledge regarding the epidemiology, diagnosis and pathogenesis of pediatric NAFLD. The review also highlights the importance of studying the underlying mechanisms of pediatric NAFLD and the need for broadening efforts in prevention and control of the main risk factors. The two main universal risk factors for NAFLD, obesity and air pollution, have broad adverse health effects, and reducing their prevalence will help abate the serious health problems associated with pediatric NAFLD.

Keywords

Fatty Liver

Child

Obesity

Environmental Exposure

Prevention and Control

Air Pollution

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Author(s):

Farahnaz Joukar:[PubMed][Scholar]
Sepiedeh Besharati:[PubMed][Scholar]
Hasan Mirpour:[PubMed][Scholar]
Fariborz Mansour Ghanaei:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Obesity and Air Pollution: Global Risk Factors for Pediatric Non-alcoholic Fatty Liver Disease

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