Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

Gu Xibing; Yang Xiaojuan; Lu Zhonghua; Wang Juanhua

doi:10.5812/kowsar.1735-143x.760

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

Author(s):

Gu Xibing^1,*,

Yang Xiaojuan¹,

Lu Zhonghua¹,

Wang Juanhua¹

1Wuxi Hospital for Infectious Diseases, Wuxi, China

Hepatitis Monthly:Vol. 11, issue 10; 810-815

Published online:Oct 31, 2011

Article type:Research Article

Received:Jan 17, 2011

Accepted:Apr 23, 2011

How to Cite:Xibing G, Xiaojuan Y, Zhonghua L, Juanhua W. Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance.Hepat Mon.2011;11(10):e70248.

Abstract

Background: It is difficult to predict what type of chronic hepatitis B (CHB) progresses to chronic severe hepatitis B.
Objectives: This study aimed to observe changes in the HBV-specific and -nonspecific cellmediated immune responses after CHB deteriorates into severe hepatic disease and explore the significance of such changes.
Patients and Methods: This study aimed to observe changes in the HBV-specific and -nonspecific cell-mediated immune responses after CHB deteriorates into severe hepatic disease and explore the significance of such changes.
Results: In 49 of 255 CHB patients (19.22%), the disease developed into chronic severe hepatitis (early stage) an average of 10.06 ± 1.73 days after admission. CD4+ and NK cells levels in Group A were lower after progression into severe hepatitis than on the second day of admission (baseline) (P < 0.01). CD8+ cells and nonspecific CTL levels in Group A were higher after progression than at baseline (P < 0.01), and latter was higher than in Group B at baseline (P < 0.01); the levels of CD8+ cells and nonspecific CTLs in Group A after progression were significantly higher than those of Group B 10 days after admission (P < 0.01). There were no significant differences in HBV-specific CTL levels in Group A before and after progression to severe hepatitis (P > 0.05).
Conclusions: Our results suggest that the immunological pathogenesis of chronic severe hepatitis B is related to significant rises in CD8+ and nonspecific CTL levels and that such increases predict that the disease will deteriorate into severe hepatitis.

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Author(s):

Gu Xibing:[PubMed][Scholar]
Yang Xiaojuan:[PubMed][Scholar]
Lu Zhonghua:[PubMed][Scholar]
Wang Juanhua:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

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