Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

1Department of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences. 2) Infectious and Tropical Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran

Hepatitis Monthly:Vol. 11, issue 10; 810-815

Published online:Oct 31, 2011

Article type:Research Article

Received:Jan 17, 2011

Accepted:Apr 23, 2011

How to Cite:Arababadi M K, Kazemi Arababadi M. Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance.Hepat Mon.2011;11(10):e93022.

Abstract

Background: It is difficult to predict what type of chronic hepatitis B (CHB) progresses to chronic severe hepatitis B.
Objectives: This study aimed to observe changes in the HBV-specific and -nonspecific cellmediated immune responses after CHB deteriorates into severe hepatic disease and explore the significance of such changes.
Patients and Methods: This study aimed to observe changes in the HBV-specific and -nonspecific cell-mediated immune responses after CHB deteriorates into severe hepatic disease and explore the significance of such changes.
Results: In 49 of 255 CHB patients (19.22%), the disease developed into chronic severe hepatitis (early stage) an average of 10.06 ± 1.73 days after admission. CD4+ and NK cells levels in Group A were lower after progression into severe hepatitis than on the second day of admission (baseline) (P < 0.01). CD8+ cells and nonspecific CTL levels in Group A were higher after progression than at baseline (P < 0.01), and latter was higher than in Group B at baseline (P < 0.01); the levels of CD8+ cells and nonspecific CTLs in Group A after progression were significantly higher than those of Group B 10 days after admission (P < 0.01). There were no significant differences in HBV-specific CTL levels in Group A before and after progression to severe hepatitis (P > 0.05).
Conclusions: Our results suggest that the immunological pathogenesis of chronic severe hepatitis B is related to significant rises in CD8+ and nonspecific CTL levels and that such increases predict that the disease will deteriorate into severe hepatitis.

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Mohammad Kazemi Arababadi:[PubMed][Scholar]
Mohammad Kazemi Arababadi:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Alteration in Cellular Immunity after Chronic Hepatitis B Deteriorated into Severe Hepatitis and Its Significance

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