The HBV DNA cutoff value for discriminating patients with HBeAgnegative chronic hepatitis B from inactive carriers

Eun Kim; Yeon Seo; Bora Keum; Ji Kim; Hyonggin An; Hyung Yim; Yong Kim; Yoon Jeen; Hoon Chun; Soon Um; Chang Kim; Ho Ryu

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

Current Issue Accepted Manuscripts All Issues In Press Articles Search

Journal Information Boards and committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

The HBV DNA cutoff value for discriminating patients with HBeAgnegative chronic hepatitis B from inactive carriers

Author(s):

Eun Sun Kim¹,

Yeon Seok Seo^2,*,

Bora Keum¹,

Ji Hoon Kim¹,

Hyonggin An¹,

Hyung Joon Yim¹,

Yong Sik Kim¹,

Yoon Tae Jeen¹,

Hoon Jai Chun¹,

Soon Ho Um¹,

Chang Duck Kim¹,

Ho Sang Ryu¹

1Departments of Internal Medicine, Korea University College of Medicine, Korea

2Departments of Internal Medicine, Korea University College of Medicine, drseo@korea.ac.kr, Korea

Hepatitis Monthly:Vol. 11, issue 5; 351-357

Published online:May 31, 2011

Article type:Research Article

Received:Aug 11, 2010

Accepted:Nov 24, 2010

How to Cite:Kim E S, Seo Y S, Keum B, Kim J H, An H, et al. The HBV DNA cutoff value for discriminating patients with HBeAgnegative chronic hepatitis B from inactive carriers.Hepat Mon.2011;11(5):351-357.

Abstract

Background: Patients with HBeAg-negative chronic hepatitis B (CHB) has a significantly different prognosis than inactive carriers; there is however, no reliable strategy for accurately differentiating these two disease conditions.
Objectives: To determine a strategy for discriminating patients with HBeAg-negative CHB from inactive carriers.
Materials and Methods: Consecutive inactive carriers (i.e. HBeAg-negativity, anti-HBe-positivity, normal ALT levels, and HBV DNA < 2000 IU/mL) were enrolled. HBV reactivation was defined as the elevation of the HBV DNA level to ≥ 2000 IU/mL. Patients were classified into true inactive carriers when their HBV DNA levels remained at < 2000 IU/mL or false inactive carriers when their HBV DNA levels increased to ≥ 2000 IU/mL during the first year.
Results: The Mean ± SD age of 208 inactive carriers (140 males) was 47.7 ± 12.6 years. The Mean ± SD serum ALT and HBV DNA levels were 22.8 ± 8.6 IU/L and 360 ± 482 IU/mL, respectively. HBV reactivation developed in 41 (19.7%) patients during the first year. Baseline HBV DNA and ALT levels differed significantly between true inactive and false inactive carriers. The AUROCs of the baseline ALT and HBV DNA levels for predicting a false inactive carrier were 0.609 and 0.831, respectively. HBV reactivation developed more often in patients with a baseline HBV DNA level of ≥ 200 IU/mL than in those with a baseline HBV DNA level of < 200 IU/mL during a Mean ± SD follow-up of 622 ± 199 days.
Conclusions: The HBV DNA level was useful for discriminating patients with HBeAg-negative CHB from true inactive carriers. The follow-up strategies applied to inactive carriers need to vary with their HBV DNA levels.

Implication for health policy/practice/research/medical education:
Due to major doubts in understanding the best strategy for differentiating between HBeAg negative and inactive carriers, this diagnostic study is recommended to all clinicians involved in treatment of patients with HBV infection.
Please cite this paper as:
Kim ES, Seo YS, Keum B, Kim JH, An H, Yim HJ, et al. The HBV DNA cutoff value for discriminating patients with HBeAg-negative chronic hepatitis B from inactive carriers. Hepat Mon. 2011;11(5):351-357.

Keywords

Hepatitis B virus

Reactivation

Inactive carrier

Full Text

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 3 days ago
Scopus by Title: 2
Last Update: 3 days ago
Scopus by Title (Ref): 2
Last Update: 3 days ago
CrossRef: 0
Last Update: 5 days ago

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Eun Kim:[PubMed][Scholar]
Yeon Seo:[PubMed][Scholar]
Bora Keum:[PubMed][Scholar]
Ji Kim:[PubMed][Scholar]
Hyonggin An:[PubMed][Scholar]
Hyung Yim:[PubMed][Scholar]
Yong Kim:[PubMed][Scholar]
Yoon Jeen:[PubMed][Scholar]
Hoon Chun:[PubMed][Scholar]
Soon Um:[PubMed][Scholar]
Chang Kim:[PubMed][Scholar]
Ho Ryu:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

Outlines

The HBV DNA cutoff value for discriminating patients with HBeAgnegative chronic hepatitis B from inactive carriers

Abstract

Full Text

Last Update: 3 days ago

Last Update: 3 days ago

Last Update: 3 days ago

Last Update: 5 days ago