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Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

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https://doi.org/10.5812/kowsar.1735143X.807

Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie

Author(s):
Sadaf BadarSadaf Badar1, Sadaf BadarSadaf Badar1, Bushra KhubaibBushra Khubaib1, Bushra KhubaibBushra Khubaib1, Muhammad IdreesMuhammad Idrees2,*, Muhammad IdreesMuhammad Idrees1,*, Abrar HussainAbrar Hussain1, Abrar HussainAbrar Hussain1, Zunaira AwanZunaira Awan1, Zunaira AwanZunaira Awan1, Sadia ButtSadia Butt1, Sadia ButtSadia Butt1, Samia AfzalSamia Afzal1, Samia AfzalSamia Afzal1, Madeeha AkramMadeeha Akram1, Madeeha AkramMadeeha Akram1, Zareen FatimaZareen Fatima1, Zareen FatimaZareen Fatima1, Mahwish AftabMahwish Aftab1, Mahwish AftabMahwish Aftab1, Sana SaleemSana Saleem1, Sana SaleemSana Saleem1, Sara MunirSara Munir1, Sara MunirSara Munir1, Bisma RauffBisma Rauff1, Bisma RauffBisma Rauff1, Mahrukh NaudhaniMahrukh Naudhani1, Mahrukh NaudhaniMahrukh Naudhani1, Ali LiaquatAli Liaquat1, Liaquat AliLiaquat Ali1, Muhammaad AliMuhammaad Ali1, Muhammaad AliMuhammaad Ali1, Irshad-ul RehmanIrshad-ul Rehman1, Irshadul RehmanIrshadul Rehman1
1National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
2National Centre of Excellence in Molecular Biology, University of the Punjab, [email protected], Pakistan
Corresponding Authors:
Hepatitis Monthly:Vol. 12, issue 1; 11-15
Published online:Dec 31, 2011
Article type:Review Article
Received:Jan 11, 2011
Accepted:Dec 27, 2011
How to Cite:Badar S, Badar S, Khubaib B, Khubaib B, Idrees M, et al. Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie. Hepat Mon. 2011;12(1):. doi: https://doi.org/10.5812/kowsar.1735143X.807

Abstract

Context:

HCV infection is strongly associated with development of insulin resistance and type-2 diabetes, however molecular mechanism of these associations is not known. The aim of this review was to conduct a comprehensive literature search to understand the nature of the association between hepatitis C virus (HCV) infection and insulin resistance (IR). We also explored the role of HCV core protein and NS5a in modulating the course of the insulin-signaling pathway.

Evidence Acquisitions:

We searched Directory of Open Access Journals (DOAJ) Google Scholar, Pubmed (NLM), LISTA (EBSCO), Web of Science (TS and PakMediNet).

Results:

Emerging evidence suggests an association between HCV infection and carotid/coronary vascular disease. IR appears to be a dominant underlying cause of accelerated atherosclerosis in patients with chronic hepatitis C (CHC). HCV can induce IR directly through the stimulation of SOCS3 and PPA2, and both of these molecules have been shown to inhibit interferon-? signaling. Improvement of insulin sensitivity may increase the response rate to antiviral treatment and prevent IR complications, including vascular diseases. The results of several clinical trials that have used insulin sensitizers (metformin and PPAR-? agonists) have been inconclusive.

Conclusions:

Beside the association between HCV and IR, the published data also have showed the possible association of HCV core and NS5A protein with IR.

Keywords
Insulin Resistance
NS5a Protein
Hepatitis C

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