Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie

Sadaf Badar; Sadaf Badar; Bushra Khubaib; Bushra Khubaib; Muhammad Idrees; Muhammad Idrees; Abrar Hussain; Abrar Hussain; Zunaira Awan; Zunaira Awan; Sadia Butt; Sadia Butt; Samia Afzal; Samia Afzal; Madeeha Akram; Madeeha Akram; Zareen Fatima; Zareen Fatima; Mahwish Aftab; Mahwish Aftab; Sana Saleem; Sana Saleem; Sara Munir; Sara Munir; Bisma Rauff; Bisma Rauff; Mahrukh Naudhani; Mahrukh Naudhani; Ali Liaquat; Liaquat Ali; Muhammaad Ali; Muhammaad Ali; Irshad-ul Rehman; Irshadul Rehman

doi:10.5812/kowsar.1735143X.807

https://doi.org/10.5812/kowsar.1735143X.807

Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie

Authors

Sadaf Badar¹, Sadaf Badar¹, Bushra Khubaib¹, Bushra Khubaib¹, Muhammad Idrees^2,*, Muhammad Idrees^1,*, Abrar Hussain¹, Abrar Hussain¹, Zunaira Awan¹, Zunaira Awan¹, Sadia Butt¹, Sadia Butt¹, Samia Afzal¹, Samia Afzal¹, Madeeha Akram¹, Madeeha Akram¹, Zareen Fatima¹, Zareen Fatima¹, Mahwish Aftab¹, Mahwish Aftab¹, Sana Saleem¹, Sana Saleem¹, Sara Munir¹, Sara Munir¹, Bisma Rauff¹, Bisma Rauff¹, Mahrukh Naudhani¹, Mahrukh Naudhani¹, Ali Liaquat¹, Liaquat Ali¹, Muhammaad Ali¹, Muhammaad Ali¹, Irshad-ul Rehman¹, Irshadul Rehman¹

1National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan

2National Centre of Excellence in Molecular Biology, University of the Punjab, idreeskhan96@yahoo.com, Pakistan

Corresponding Authors:

*Corresponding author at: Muhammad Idrees, National Centre of Excellence in Molecular Biology, 87-West Canal Bank, Road Thokar Niaz Baig Lahore-53700, University of the Punjab, Lahore, Pakistan. Tel.: + 92-425293141, Fax: +92-425293149, E-mail:, idreeskhan96@yahoo.com. Email: idreeskhan96@yahoo.com

Hepatitis Monthly:Vol. 12, issue 1; 11-15

Published online:Dec 31, 2011

Article type:Review Article

Received:Jan 11, 2011

Accepted:Dec 27, 2011

How to Cite:Badar S, Badar S, Khubaib B, Khubaib B, Idrees M, et al. Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie. Hepat Mon. 2011;12(1):. doi: https://doi.org/10.5812/kowsar.1735143X.807

Abstract

Context:

HCV infection is strongly associated with development of insulin resistance and type-2 diabetes, however molecular mechanism of these associations is not known. The aim of this review was to conduct a comprehensive literature search to understand the nature of the association between hepatitis C virus (HCV) infection and insulin resistance (IR). We also explored the role of HCV core protein and NS5a in modulating the course of the insulin-signaling pathway.

Evidence Acquisitions:

We searched Directory of Open Access Journals (DOAJ) Google Scholar, Pubmed (NLM), LISTA (EBSCO), Web of Science (TS and PakMediNet).

Results:

Emerging evidence suggests an association between HCV infection and carotid/coronary vascular disease. IR appears to be a dominant underlying cause of accelerated atherosclerosis in patients with chronic hepatitis C (CHC). HCV can induce IR directly through the stimulation of SOCS3 and PPA2, and both of these molecules have been shown to inhibit interferon-? signaling. Improvement of insulin sensitivity may increase the response rate to antiviral treatment and prevent IR complications, including vascular diseases. The results of several clinical trials that have used insulin sensitizers (metformin and PPAR-? agonists) have been inconclusive.

Conclusions:

Beside the association between HCV and IR, the published data also have showed the possible association of HCV core and NS5A protein with IR.

Highlights

KeywordsInsulin Resistance NS5a Protein Hepatitis C

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Copyright

© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Outline

Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie

Abstract

Context:

Evidence Acquisitions:

Results:

Conclusions:

Highlights

Full Text

Copyright

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