Logo
homeHome

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

Hepatitis Monthly

homeHome
helpInstructions
format_list_bulletedAPC
Authors GuideSubmit Manuscript

Outlines

https://doi.org/10.5812/kowsar.1735143X.807

Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie

Author(s):
Sadaf BadarSadaf Badar1, Sadaf BadarSadaf Badar1, Bushra KhubaibBushra Khubaib1, Bushra KhubaibBushra Khubaib1, Muhammad IdreesMuhammad Idrees2,*, Muhammad IdreesMuhammad Idrees1,*, Abrar HussainAbrar Hussain1, Abrar HussainAbrar Hussain1, Zunaira AwanZunaira Awan1, Zunaira AwanZunaira Awan1, Sadia ButtSadia Butt1, Sadia ButtSadia Butt1, Samia AfzalSamia Afzal1, Samia AfzalSamia Afzal1, Madeeha AkramMadeeha Akram1, Madeeha AkramMadeeha Akram1, Zareen FatimaZareen Fatima1, Zareen FatimaZareen Fatima1, Mahwish AftabMahwish Aftab1, Mahwish AftabMahwish Aftab1, Sana SaleemSana Saleem1, Sana SaleemSana Saleem1, Sara MunirSara Munir1, Sara MunirSara Munir1, Bisma RauffBisma Rauff1, Bisma RauffBisma Rauff1, Mahrukh NaudhaniMahrukh Naudhani1, Mahrukh NaudhaniMahrukh Naudhani1, Ali LiaquatAli Liaquat1, Liaquat AliLiaquat Ali1, Muhammaad AliMuhammaad Ali1, Muhammaad AliMuhammaad Ali1, Irshad-ul RehmanIrshad-ul Rehman1, Irshadul RehmanIrshadul Rehman1
1National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
2National Centre of Excellence in Molecular Biology, University of the Punjab, [email protected], Pakistan
Corresponding Authors:
*Corresponding author at: Muhammad Idrees, National Centre of Excellence in Molecular Biology, 87-West Canal Bank, Road Thokar Niaz Baig Lahore-53700, University of the Punjab, Lahore, Pakistan. Tel.: + 92-425293141, Fax: +92-425293149, E-mail:, [email protected]. Email: [email protected]
*Corresponding author at: Muhammad Idrees, National Centre of Excellence in Molecular Biology, 87-West Canal Bank, Road Thokar Niaz Baig Lahore-53700, University of the Punjab, Lahore, Pakistan. Tel.: + 92-425293141, Fax: +92-425293149, E-mail:, [email protected]. Email: [email protected]
Hepatitis Monthly:Vol. 12, issue 1; 11-15
Published online:Dec 31, 2011
Article type:Review Article
Received:Jan 11, 2011
Accepted:Dec 27, 2011
How to Cite:Badar S, Badar S, Khubaib B, Khubaib B, Idrees M, et al. Association of Hepatitis C Virus With Insulin Resistance: Evidences From Animal Studies and Clinical Studie. Hepat Mon. 2011;12(1):. doi: https://doi.org/10.5812/kowsar.1735143X.807

Abstract

Context:

HCV infection is strongly associated with development of insulin resistance and type-2 diabetes, however molecular mechanism of these associations is not known. The aim of this review was to conduct a comprehensive literature search to understand the nature of the association between hepatitis C virus (HCV) infection and insulin resistance (IR). We also explored the role of HCV core protein and NS5a in modulating the course of the insulin-signaling pathway.

Evidence Acquisitions:

We searched Directory of Open Access Journals (DOAJ) Google Scholar, Pubmed (NLM), LISTA (EBSCO), Web of Science (TS and PakMediNet).

Results:

Emerging evidence suggests an association between HCV infection and carotid/coronary vascular disease. IR appears to be a dominant underlying cause of accelerated atherosclerosis in patients with chronic hepatitis C (CHC). HCV can induce IR directly through the stimulation of SOCS3 and PPA2, and both of these molecules have been shown to inhibit interferon-? signaling. Improvement of insulin sensitivity may increase the response rate to antiviral treatment and prevent IR complications, including vascular diseases. The results of several clinical trials that have used insulin sensitizers (metformin and PPAR-? agonists) have been inconclusive.

Conclusions:

Beside the association between HCV and IR, the published data also have showed the possible association of HCV core and NS5A protein with IR.

Keywords
Insulin Resistance
NS5a Protein
Hepatitis C

Full Text

Full text is available in PDF

Copyright

© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Similar Articles

29
Dec
2014

Insulin Resistance Provides the Connection Between Hepatitis C Virus and Diabetes

Sher Zaman Safi,
Humaira Shah,
Gracie Ong Siok Yan,
Rajes Qvist

Safi SZ, Shah H, Siok Yan GO, Qvist R. Insulin Resistance Provides the Connection Between Hepatitis C Virus and Diabetes. Hepat Mon. 2015;15(1):e23941. doi: https://doi.org/10.5812/hepatmon.23941

30
Sep
2008

The Emerging Extrahepatic Manifestations of Hepatitis C Virus Infection in Chronic Hepatitis and Mixed Cryoglobulinemia

Poupak Fallahi,
Clodoveo Ferri,
Silvia Martina Ferrari,
Alessandro Pampana,
Domenico Sansonno,
Alessandro Antonelli

Fallahi P, Ferri C, Ferrari S, Pampana A, Sansonno D, et al. The Emerging Extrahepatic Manifestations of Hepatitis C Virus Infection in Chronic Hepatitis and Mixed Cryoglobulinemia. Hepat Mon. 2008;8(3):. doi:

11
Aug
2014

Hepatitis C Virus Capsid Protein and Intracellular Lipids Interplay and itsAssociation With Hepatic Steatosis

Muhammad Sohail Afzal,
Najam Us Sahar Sadaf Zaidi,
Jean Dubuisson,
Yves Rouille

Afzal MS, Zaidi NUSS, Dubuisson J, Rouille Y. Hepatitis C Virus Capsid Protein and Intracellular Lipids Interplay and itsAssociation With Hepatic Steatosis. Hepat Mon. 2014;14(8):e17812. doi: https://doi.org/10.5812/hepatmon.17812

2
Dec
2020
Hepatitis Monthly

Investigating the Relationship Between Insulin Resistance and Fatty Liver in a Random Population of Tehran

Hossein Moameri,
Zahra Akbarzade,
Elmira Khamisi,
Saeed Osati,
Alireza Ghaemi,
Elham Ehrampoush
,et al.

Moameri H, Akbarzade Z, Khamisi E, Osati S, Ghaemi A, et al. Investigating the Relationship Between Insulin Resistance and Fatty Liver in a Random Population of Tehran. Hepat Mon. 2020;20(10):e102972. doi: https://doi.org/10.5812/hepatmon.102972

31
Jan
2012

Hepatitis C Virus Cryoglobulinemia and Non-Hodgkin Lymphoma

Zohreh Jadali,
Zohreh Jadali

Jadali Z, Jadali Z. Hepatitis C Virus Cryoglobulinemia and Non-Hodgkin Lymphoma. Hepat Mon. 2012;12(2):. doi: https://doi.org/10.5812/hepatmon.818

Download PDF298.91 KB
Import into EndNoteImport into BibTex
Crossmark

Crossmark

Checking

Share on
Comments
Number of Comments:0
Cited by
Metrics
Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC 

Search Relations

Author(s):

Related Articles

Related Article in PubMed

Related Article in Google Scholar

Create Citation Alert via Google Reader