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Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

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https://doi.org/10.5812/hepatmon.7240

S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma

Author(s):
Claudia MaletzkiClaudia Maletzki1, Peggy BodammerPeggy Bodammer3, Anne BreitrckAnne Breitrck4, Claus KerkhoffClaus Kerkhoff4,*
1Department of General Surgery, Division of Molecular Oncology and Immunotherapy, University of Rostock, Germany
3Fraunhofer Institute for Cell Therapy and Immunology, Department of Immunology, AG Extracorporeal Immune Modulation (EXIM), Germany
4Department of Internal Medicine, Division of Nephrology, University of Rostock, [email protected], Germany
Hepatitis Monthly:Vol. 12, issue 10; 7240
Published online:Oct 12, 2012
Article type:Review Article
Received:Jun 02, 2012
Accepted:Jul 16, 2012
How to Cite:Maletzki C, Bodammer P, Breitrck A, Kerkhoff C. S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma. Hepat Mon. 2012;12(10):7240. doi: https://doi.org/10.5812/hepatmon.7240

Abstract

Context:

Clinical and experimental studies have suggested a link between S100 gene expression and neoplastic disorders, however, the molecular mechanisms of this association are not well understood. The aim of this review was to conduct a comprehensive literature search in order to understand the possible underlying molecular mechanisms of this association. We also discuss their application as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma.

Evidence Acquisitions:

We searched Pubmed (NLM) and Web of Science (ISI Web of Knowledge).

Results:

S100 genes display a complex expression pattern in colorectal and hepatocel lular carcinoma. They are expressed in tumor and/or tumor stroma cells, and they exert both pro- and antitumorigenic actions. In view of this complexity, it becomes clear that S100 proteins might act as both friend and foe. The biological role of the S100 genes is predicted to depend on the relative contributions of the different cell types at specific stages of tumor progression.

Conclusions:

Further research is required in order to uncover the functional role of S100 genes in tumorigenesis. Answers to this issue are needed before we can more fully understand the clinical relevance of S100 protein expression within epithelial tumors, with regard to their potential applicability as biomarkers for diagnosis and therapy decisions.

Keywords
Biological Markers
Cell Transformation
Neoplastic
Matrix Metalloproteinases

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