Official Journal of Research Center for Gastroenterology and Liver Diseases
Authors
1, Mehrdad Ravanshad 1,*, Seyed Reza Reza Mohebbi2,*, Hamed Naghoosi 2, Mohamad Ebrahim Abrahim Tahaei 2, Seyed Dawood Dawood Mousavi Nasab 1, Sara Romani2, Pedram Azimzadeh2, Azar Sanati 2, Mohammad Reza Reza Zali 2chronic hepatitis B virus (HBV) infection is a multifactorial disease that can result in serious clinical complications. Host genetic background especially the genes that encode immunologic factors like INF-? and its receptor (IFN-? R) are critical in the pathogenesis of infection.
The current study aimed to investigate the association between two single nucleotide polymorphisms (SNPs) at positions -611 and -56 within the promoter region of gamma interferon receptor1 gene (IFN-? R1) and chronic HBV infection.
Genomic DNA from peripheral blood samples of 200 chronically HBV infected patients and 200 healthy blood donors, as controls, were collected and genomic DNA was extracted by phenol-chloroform method and DNA analysis genotype identification was performed by PCR-RFLP.
The results indicated that both SNPs frequency had a significant difference in the patient and control groups. At position -56, TT genotype was associated with patient group and P value was 0.002 and at position -611, GG genotype was further observed in control group and P value was 0.006.
Presence of G allele at position -611 within promoter of IFN-? R1 gene in the enrolled population for the study was related to lower risk of disease, and presence of T allele at position -56 was also related to susceptibility to chronic HBV infection. Men had higher frequency of chronic HBV infection, which might be the result of high risk behavior.
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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