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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Interferon-Alpha Induced and Ribavirin Induced Thyroid Dysfunction in Patients with Chronic Hepatitis C
Authors
1Department of Physiology, Army Medical College, nadeemamina@yahoo.com, Islamabad, Pakistan
2Department of Physiology, Army Medical College, Islamabad, Pakistan
3Department of Physiology, Shifa College of Medicine, Islamabad, Pakistan
*Corresponding Author: Department of Physiology, Army Medical College, nadeemamina@yahoo.com, Islamabad, Pakistan. Tel: +92 321 523 1807. Fax: +92 321 523 1807. Email: nadeemamina@yahoo.com
Published online:Jun 30, 2010
Article type:Review Article
Received:Sep 10, 2009
Accepted:Feb 26, 2010
How to Cite:Nadeem A, Hussain M, Aslam M, Hussain T. Interferon-Alpha Induced and Ribavirin Induced Thyroid Dysfunction in Patients with Chronic Hepatitis C. Hepat Mon. 2010;10(2):. doi:
Abstract
Chronic hepatitis C (CHC) is one of the commonest infectious diseases of the liver and may lead to cirrhosis or hepatocellular carcinoma. Combination therapy with pegylated interferon (PEG-IFN) and Ribavirin is the treatment of choice for CHC. Combination therapy is thought to act by means of antiviral mechanisms and immunomodulation. Thyroid dysfunction is the most common autoimmune adverse effect associated with combination therapy; hypothyroidism is more common than hyperthyroidism. Antithyroid antibodies and female sex have a predictive value in the development of interferon
induced thyroid disease (IITD). Patients with CHC should be informed of the possibility of side effects on the thyroid gland. Screening for antithyroid antibodies and thyroid function tests should be performed in patients with CHC before the commencement of antiviral treatment, and during and after it. This article reviews different aspects of IITD, including its pathogenesis, clinical manifestations, association with treatment regimens and treatment response and the outcome of thyroid dysfunction.
Highlights
Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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