Seroprevalence Study of Hepatitis C and Hepatitis B Virus among Hospitalized Intravenous Drug Users in Ahvaz, Iran (2002-2006)

Seyed Alavi; Fatemeh Behdad

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Seroprevalence Study of Hepatitis C and Hepatitis B Virus among Hospitalized Intravenous Drug Users in Ahvaz, Iran (2002-2006)

Author(s):

Seyed Mohammad Alavi^1,*,

Fatemeh Behdad²

1Infectious and Tropical Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, [email protected], Khoozestan, IR.Iran

2Infectious Disease Division, Razi Hospital, Ahvaz Jundishapur University of Medical Sciences, Khoozestan, IR.Iran

Hepatitis Monthly:Vol. 10, issue 2; 101-104

Published online:Jun 30, 2010

Article type:Research Article

Received:Dec 03, 2009

Accepted:Mar 18, 2010

How to Cite:Alavi S, Behdad F. Seroprevalence Study of Hepatitis C and Hepatitis B Virus among Hospitalized Intravenous Drug Users in Ahvaz, Iran (2002-2006). Hepat Mon. 2010;10(2):. doi:

Abstract

Background and Aims: Viral hepatitis is a serious complication among intravenous drug users (IDUs). The objectives of this study were to determine the seroprevalence of hepatitis B and C viruses (HBV and HCV), and associated risk factors among IDUs at a teaching hospital in Ahvaz, southwest Iran.

Methods: Medical records of 333 IDUs hospitalized from 2002 to 2006 at Razi Hospital, which is affiliated to Ahvaz Jundishapur University of Medical Sciences, were reviewed. Cases meeting the criteria for a diagnosis of viral hepatitis infection were included in this study. Patients’ characteristics, clinical and laboratory findings were extracted. Data of cases with hepatitis virus infection (HIV), called the HIV group and without HIV, called the NHIV group, were compared, using the chi-square test for qualitative variables and the t-test for quantitative variables. Differences with a P < 0.05 were considered significant.

Results: Out of a total of 333 IDUs, 115 (34.5%), mostly male, with a mean age of 24.8±6.2 had HIV. More than 65% had a history of imprisonment. The mean duration of IDU was 4.5±1.6 years for the HIV group and 1.8±0.4 years for the NHIV group (P < 0.05). 85% of the HIV group and 45% of the NHIV group shared injection equipment (P < 0.05). 103 patients (30.9%) had HCV and 12 (3.6%) had HBV infection. There was a significant difference in age, duration of drug abuse, time spent in prison, sharing injection equipment, history of surgery, blood transfusion, packs of cigarettes per year and human immunodeficiency virus (HIV) co-infection between the two groups (P < 0.05).

Conclusions: HIV in IDU population is a prevalent complication, and is associated with heavy smoking (high number of packs of cigarettes per year), sharing injection equipment, long duration of drug usage, long duration of prison stay, HIV co-infection, history of surgery, blood and blood products transfusion. Older age, longer duration of IDU and imprisonment put the cases at higher risk of acquiring HCV in comparison to HBV.

Keywords

Intravenous Drug Users

Viral Hepatitis

HBV

HCV

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Author(s):

Seyed Alavi:[PubMed][Scholar]
Fatemeh Behdad:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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Seroprevalence Study of Hepatitis C and Hepatitis B Virus among Hospitalized Intravenous Drug Users in Ahvaz, Iran (2002-2006)

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