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Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Intraperitoneal Transplantation of Hepatocytes Embedded in Thermoreversible Gelation Polymer (Mebiol Gel) in Acute Liver Failure Rat Model
Authors
Nyamathulla Parveen1, Aleem Ahmed Khan2,*, Subramani Baskar3, Mohammad Aejaz Habeeb1, Ravindra Babu1, Samuel Abraham3, Hiroshi Yoshioka4, Yuichi Mori4, Habibullah Chittoor Mohammad1
1Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, India
2Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, aleem_a_khan@rediffmail.com, A.P., India
3Nichi-In Centre for Regenerative Medicine, India
4Advance Research Centre for Science and Engineering, Waseda University, Japan
*Corresponding Author: Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, aleem_a_khan@rediffmail.com, A.P., India. Tel: +91 040 24342954. Fax: +91 040 24342954. Email: aleem_a_khan@rediffmail.com
Published online:Dec 31, 2008
Article type:Research Article
Received:May 15, 2008
Accepted:Sep 18, 2008
How to Cite:Parveen N, Khan A, Baskar S, Habeeb M, Babu R, et al. Intraperitoneal Transplantation of Hepatocytes Embedded in Thermoreversible Gelation Polymer (Mebiol Gel) in Acute Liver Failure Rat Model. Hepat Mon. 2008;8(4):. doi:
Abstract
Orthotopic liver transplantation (OLT) is the only treatment that improves the survival rate in patients with acute liver failure (ALF). Hepatocytes are anchorage dependent and require a substratum for their long-term survival. Various substrata are being used to improve the function and survival of these hepatocytes, but cannot be used clinically as they are animal derived. This has been overcome by thermoreversible gelation polymer (TGP). In the present study, rat hepatocytes embedded in TGP, were transplanted intraperitoneally in acute liver failure rat model. Efficacy of the transplanted cells was studied by assessing biochemical parameters and histopathology at different time points. The ALF condition reverted to normal 15 days after cell transplantation. The transplanted animals survived 100%. Therefore this study suggests that the cells in TGP provide substratum to the transplanted cells for long term survival and could successfully provide liver support in severe ALF.
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Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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