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24 resultsUpdated October 23, 2026
1

Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles

Frontiers in Bioengineering and Biotechnology 6 (2019)

Larissa Pereira Brumano; Francisco Vitor Santos da Silva; Tales Alexandre Costa-Silva; Alexsandra Conceição Apolinário; João H. P. M. Santos; Eduardo Krebs Kleingesinds; Gisele Monteiro; Carlota de Oliveira Rangel‐Yagui; Brahim Benyahia; Adalberto Pessoa

2

Therapeutic enzymes: Discoveries, production and applications

Journal of Drug Delivery Science and Technology 63 (2021)

Siddhi Tandon; Anjali Sharma; Shikha Singh; Sumit Sharma; Saurabh Jyoti Sarma

3

Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions

Pharmaceutics 14(3) (2022)

M. V. Pokrovskaya; Vadim S. Pokrovsky; С. С. Александрова; Nikolay N. Sokolov; Dmitry D. Zhdanov

4

Microbial production, molecular modification, and practical application of l-Asparaginase: A review

International Journal of Biological Macromolecules 186 (2021)

Yiming Wang; Wei Xu; Hao Wu; Wenli Zhang; Cuie Guang; Wanmeng Mu

5

Engineering and Expression Strategies for Optimization of L-Asparaginase Development and Production

International Journal of Molecular Sciences 24(20) (2023)

Anastasia N. Shishparenok; Yulia A. Gladilina; Dmitry D. Zhdanov

6

Staggered Target SELEX, a novel approach to isolate non-cross-reactive aptamer for detection of SEA by apta-qPCR

Journal of Biotechnology 286 (2018)

Hamid Sedighian; Raheleh Halabian; Jafar Amani; Mohammad Heiat; Mohsen Amin; Abbas Ali Imani Fooladi

7

Breast cancer targeted/ therapeutic with double and triple fusion Immunotoxins

The Journal of Steroid Biochemistry and Molecular Biology 200 (2020)

Zoleikha Goleij; Hamideh Mahmoodzadeh Hosseini; Hamid Sedighian; Elham Behzadi; Raheleh Halabian; Rahim Sorouri; Abbas Ali Imani Fooladi

8

A potential type-II L-asparaginase from marine isolate Bacillus australimaris NJB19: Statistical optimization, in silico analysis and structural modeling

International Journal of Biological Macromolecules 174 (2021)

Namrata Chakravarty; P. Priyanka; Jyoti Singh; R. P. Singh

9

Towards development of biobetter: L-asparaginase a case study

Biochimica et Biophysica Acta (BBA) - General Subjects 1868(1) (2023)

Rajan K. Tripathy; J. Anakha; Abhay H. Pande

10

A structural in silico analysis of the immunogenicity of l-asparaginase from Escherichia coli and Erwinia carotovora

Biologicals 59 (2019)

Lisandra Herrera Belén; Jorge Félix Beltrán Lissabet; Carlota de Oliveira Rangel‐Yagui; Brian R. Effer; Gisele Monteiro; Adalberto Pessoa; Jorge G. Farías

11

Immunogenicity assessment of fungal l-asparaginases: an in silico approach

SN Applied Sciences 2(2) (2020)

Lisandra Herrera Belén; Jorge Félix Beltrán Lissabet; Carlota de Oliveira Rangel‐Yagui; Gisele Monteiro; Adalberto Pessoa; Jorge G. Farías

12

A Structural In Silico Analysis of the Immunogenicity of L-Asparaginase from Penicillium cerradense

International Journal of Molecular Sciences 25(9) (2024)

Kellen Cruvinel Rodrigues Andrade; Maurício Homem-de-Mello; Julia Almeida Motta; Marina Borges Guimarães; Joel Antônio Cordeiro de Abreu; Paula Monteiro Souza; Adalberto Pessoa; Georgios Joannis Pappas Jr; Pérola Oliveira Magalhães

13

In Silico Evaluation of Two Targeted Chimeric Proteins Based on Bacterial Toxins for Breast Cancer Therapy

International Journal of Cancer Management In Press(In Press) (2019)

Zoleikha Goleij; Hamideh Mahmoodzadeh Hosseini; Mohsen Amin; Jafar Amani; Elham Behzadi; Abbas Ali Imani Fooladi

14

Harnessing an Integrative In Silico Approach to Engage Highly Immunogenic Peptides in an Antigen Design Against Epsilon Toxin (ETX) of Clostridium perfringens

International Journal of Peptide Research and Therapeutics 27(2) (2020)

Mahdieh Mahboobi; Hamid Sedighian; Ehsan Malekara; Saeed Khalili; Mohammad Reza Rahbar; Kobra Ahmadi Zanoos; Raheleh Halabian; Abolfazl Jahangiri

15

Expression and Biological Evaluation of an Engineered Recombinant L-asparaginase Designed by In Silico Method Based on Sequence of the Enzyme from Escherichia coli

Advanced Pharmaceutical Bulletin 13(4) (2023)

Mahrokh Dastmalchi; Mahdiyeh Alizadeh; Omid Jamshidi Kandjani; Hassan Rezazadeh; Maryam Hamzeh‐Mivehroud; Mohammad M. Farajollahi; Siavoush Dastmalchi

16

Toward Safer Biotherapeutics: Expression and Characterization of a Humanized Chimeric L-Asparaginase in E. coli

International Journal of Molecular Sciences 26(14) (2025)

Alejandro Pedroso; Javiera Miranda; Nicolás Lefin; Brian R. Effer; Enrique Pedroso Reyanldo; Yolanda Calle; Gisele Monteiro; Adalberto Pessoa; Jorge G. Farías

17

Investigating Functional and Folding Stability of an Engineered E. coli L-asparaginase Harboring Y176F/S241C Mutations

Advanced Pharmaceutical Bulletin 14(3) (2024)

Mahrokh Dastmalchi; Maryam Hamzeh‐Mivehroud; Hassan Rezazadeh; Mohammad M. Farajollahi; Siavoush Dastmalchi

18

Bacteria and Bacteria-Based Products in Cancer Therapy: Current Status and Future Advances

Springer eBooks (2023)

Nikita Jangra; Anubhuti Kawatra; Rakhi Dhankhar; Pooja Gulati

19

Comparison of Immune Response in Mice Immunized with Recombinant PreS2/S-C18-27 Protein Derived from Hepatitis B Virus with Commercial Vaccine

Iranian journal of pathology 17(4) (2022)

Elaheh Gholami Parizad; Abbas Ali Imani Fooladi; Hamid Sedighian; Elham Behzadi; Azar Valizadeh; Afra Khosravi

20

Approaches for improving L-asparaginase expression in heterologous systems

Biomeditsinskaya Khimiya 69(1) (2023)

Yulia A. Gladilina; Anastasia N. Shishparenok; Dmitry D. Zhdanov

21

Immune response induced by recombinant pres2/S-protein and a pres2-S-protein fused with a core 18-27 antigen fragment of hepatitis B virus compared to conventional HBV vaccine

Virus Genes 59(4) (2023)

Elaheh Gholami Parizad; Abbas Ali Imani Fooladi; Hamid Sedighian; Elham Behzadi; Jafar Amani; Afra Khosravi

22

Heterologous Expression of Recombinant L-asparaginase Genes

Biomedical Chemistry Research and Methods 8(4) (2025)

M. V. Pokrovskaya; S.S. Alexandrova; Vadim S. Pokrovsky; Natalia V. Dobryakova; Anastasia N. Shishparenok; Yu.V. Gladilina; Dmitry D. Zhdanov

23

Protein Engineering of L-Asparaginase II to Reduce Immunogenicity for Acute Lymphoblastic Leukemia Therapy

Biointerface Research in Applied Chemistry 16(3) (2026)

Pegah Akbari Amjad; Zeinab Amin; Mehrnaz Bahreini; Maryam Mohammadi; Zarrin Minuchehr; Bijan Bambai; Najaf Allahyari Fard