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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Detection of Somatic mutation of codon 248 of p53 gene between Iranian women with breast cancer
Authors
1Department of Medical biochemistry, Iran Pasture Institute, Karaj, Iran
2Department of Pathology, Imam Khomeini cancer Institute, Imam Khomeini hospital, Tehran, Iran
*Corresponding Author: Corresponding author: Nasrin Shojaie, Department of Medical biochemistry, Iran Pasture Institute, Karaj, Iran, Tel: +98-9125426316, Fax: +98-2177865539, E-mail: Email: nasrin_shojaie@hotmail.com
Published online:Jan 30, 2008
Article type:Research Article
Received:Jan 30, 2008
Accepted:Jan 30, 2008
How to Cite: Shojaie N, Tirgari F. Detection of Somatic mutation of codon 248 of p53 gene between Iranian women with breast cancer. Int J Cancer Manag. 2008;1(1):e80392. doi:
Abstract
Objective: Detection of P53 gene mutation on its codon 248 between Iranian women with breast cancer by PCR-RFLP.
Material and methods: DNA extraction of tumor tissues was performed in 53 patients with primary breast cancer. Designing primer for the sub-studying codon was performed with NTIVector software and detection of codon 248 mutation was done by Msp I PCR_RFLP.
Results: The somatic mutations of P53 on codon 248 were observed in 11.3% (6 of 53) of our cases, in which 9.4% were heterozygote mutation and the rest were homozygote mutation. This ratio is the highest reported percentage in the world.
Conclusion: This perusal indicates genotyping of P53 gene on codon 248 is important for Iranian women with breast cancer risk factors.
Highlights
Copyright
© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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