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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings
Authors
Mashaallah Babashahi1, Mitra Mehrazma2,*, Seyed Javad Nasiri3, Farid Azizi Jalilian4, Mostafa Rezaei-Tavirani5
1Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran
2Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
3Dept. of Pathology , Ali-Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran
4Dept. of Medical Microbiology, Ilam University of Medical Sciences, Ilam, Iran
5Proteomics Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Mitra Mehrazma, Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran, Tel: +98-2122222041-5, E-mail: Email: mitmehr@yahoo.com
Published online:Sep 30, 2013
Article type:Research Article
Received:Jan 02, 2013
Accepted:Feb 14, 2013
How to Cite:Babashahi M, Mehrazma M, Nasiri SJ, Azizi Jalilian F, Rezaei-Tavirani M. Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings. Int J Cancer Manag. 2013;6(3):e80429. doi:
Abstract
Background: Wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. Her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival.
Methods: In the current study, we analyzed Her2/neu expression in 40 Wilms' tumors. The clinico-demographic data of 40 patients with Wilms' tumor were retrieved. Immunohistochemical staining for HER2/neu was performed. Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system.
Results: Among the 38 specimens with epithelial component, 68.5% were positive for Her2/neu, whereas there was immunoreactivity in 37% of 38 blastemal, and 12% of 31 stromal components. The Her2/neu expression was significantly higher in early stages (81.5%) than in advanced stages (36.4%) in epithelial component, but not in other components.
Conclusion: This study suggested that Her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. No significant relationship was found between Her2/neu positivity and tumor size and patient's age and gender.
Highlights
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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