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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients
Authors
Sona Dalilan1, Mostafa Rezaei Tavirani2,*, Mohammad Nabiuni3, Saeed Heidari-Keshel2, Mona Zamanian Azodi2, Hakimeh Zali2
1Science and Research Branch, Islamic Azad University, Tehran, Iran
2Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Dept. of Biology, Faculty of Basic Sciences, Tarbiat Moallem University, Tehran, Iran
*Corresponding Author: Corresponding author: Mostafa Rezaei Tavirani, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Tel: +98-2122714248, E-mail: Email: rezaei.tavirani@ibb.ut.ac.ir
Published online:Dec 30, 2013
Article type:Research Article
Received:Jun 01, 2013
Accepted:Jul 02, 2013
How to Cite:Dalilan S, Rezaei Tavirani M, Nabiuni M, Heidari-Keshel S, Zamanian Azodi M, et al. Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients. Int J Cancer Manag. 2013;6(4):e80471. doi:
Abstract
Background: There are several types of cancer, which cause millions of deaths worldwide every year. Many studies have confirmed that plants are adequate natural sources to be examined as anti-cancer drugs with fewer side effects than chemotherapy and radiotherapy. In this study the anti-cancer properties of Lavender aqueous extract on lymphocytes derived from patients with Hodgkin's lymphoma has been studied.
Methods: In order to determine the cytotoxic effects of the extract on lymphocytes of patients in stages III and IV of Hodgkin's lymphoma and two different cell lines in the presence of different concentrations of aqueous extract of Lavender, MTT colorimetric assay and flow cytometry analysis were used.
Results: Findings indicated that Lavender inhibited cell proliferation in both lymphocytes and cell lines with different effects. The effective concentration of Lavender that decreased viability of Hodgkin's lymphoma cells below Lethal Concentration 50 (LC50) value was 100 µg/ml and this was half of the therapeutic dose. In addition, apoptosis was the main mechanism the Hodgkin's lymphoma cell encountered when exposed to the aqueous extract of Lavender.
Conclusion: This experiment proposes that aqueous Lavender extract can be regarded as a potential anti-cancer agent in future studies.
Highlights
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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