Relationship Between Insulin like Growth Factor-1 and Leptin in Type II Diabetic Patients

N Zarghami; G Mohammad Zadeh; P Karimi

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

Current Issue All Issues In Press Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

Relationship Between Insulin like Growth Factor-1 and Leptin in Type II Diabetic Patients

Author(s):

N Zarghami^1,*,

G Mohammad Zadeh²,

P Karimi³

1Drug Applied Research Center, Tabriz University of Medical Sciences, [email protected], Iran

2De-partment of Clinical Biochemistry, faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Iran

3Drug Applied Research Center, Tabriz University of Medical Sciences, Iran

International Journal of Endocrinology and Metabolism:Vol. 7, issue 1; 26-34

Published online:Jan 31, 2009

Article type:Research Article

Received:Feb 28, 2009

Accepted:Jul 06, 2009

How to Cite:Zarghami N, Mohammad Zadeh G, Karimi P. Relationship Between Insulin like Growth Factor-1 and Leptin in Type II Diabetic Patients. Int J Endocrinol Metab. 2009;7(1):. doi:

Abstract

Background:Diabetes is a common endocrine disease in humans. Leptin secretion is influ-enced by many factors and although the growth hormone/insulin like growth factor (GH/IGF) axis plays an important role in the regulation of body compo-sition, the physiological interaction between Leptin and IGF-1 system remain unknown. The aim of this study was to investigate the correla-tion between Leptin and IGF-1 in type II diabet-ics and controls.
Materials and Methods: This case-control study was consisted of 38, type 2 diabetics (20 males and 18 females, mean age 49.33 ± 11.33,years) and 46 healthy controls (16 males and 30 females, mean age 49.52 ± 7.99,years). We measured the concentrations of fasting plasma glucose (FPG), IGF-1, hemoglobin A1C (HbA1c) and insulin like growth factor binding protein-3(IGFBP-3) in both groups. FPG was measured by the enzymat-ic glucose oxidase method and the Hb Gold ana-lyzer HPLC was used to measure HbA1C. For de-termination of leptin, IGF-1, IGFBP-3 and insu-lin concentrations, the enzyme linked immuno-sorbent assay (ELISA) method was used. P< 0.05 was considered statistically significant.
Results: Means of BMI and age did not differ significantly between the two groups. Mean se-rum levels of IGF-1, leptin, insulin, FPG and HbA1c concentrations in type 2 diabetics were significantly higher than in controls (p<0.05). In both groups, mean serum levels of leptin in males, were statistically lower than in females. Strong correlations were found between IGF-1 and IGFBP-3, leptin and insulin, IGF-1 and age, and between BMI and FPG in both patients and controls (p<0.05). A negative correlation was ob-served between IGF-1 and HbA1c in patients and controls (p< 0.05).
Conclusion: It is concluded that leptin and the IGF-1 system, could influence body composition and fat content, particularly in obese and over-weight diabetic patients.

Keywords

IGF-1/IGFBP molar ratio

Full Text

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 0
Last Update: 1 week ago
CrossRef: 0
Last Update: 4 hours ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

N Zarghami:[PubMed][Scholar]
G Mohammad Zadeh:[PubMed][Scholar]
P Karimi:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

Relationship Between Insulin like Growth Factor-1 and Leptin in Type II Diabetic Patients

Abstract

Full Text

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 4 hours ago