Relation Between Leptin and Insulin In Patients With Type II Diabetes Mellitus

Since leptin and insulin are reported to control glucose metabolism, a relationship between these two hormones should reveal the metabolic effect of them hormones on glucose metabolism. In this study, the relationship between leptin and insulin was evaluated in obese type II diabetic patients, BMI>30 kg/m2 (group A), and non-obese type II diabetic patients, BMI<25kg/ m2 (Group B).Materials and Methods: 49 subjects were studied. Of these, 32 subjects (4 male and 28 female) were group A and 17 subjects (8 male and 9 female) were group B; both groups were analyzed for Leptin, Insulin, and HbA1c. Results: The results obtained showed leptin, insulin and HbA1c levels of 5.16±1.2 µg/ L, 6.75±1.2 µIu/mL and 9.38±0.56% for group B, these levels being 21.8±11.2 µg/L, 11.44±5.8 µIu/ml and 8.76± 0.36% for group A. Conclusion: The results of this study show that plasma leptin concentrations increased with body mass index. Plasma leptin levels in obese diabetics, in comparison to non-obese diabetic individuals, were four times higher (p=0.001). Statistical analysis indicates a direct correlation between fasting blood leptin and insulin (r=0.598 p=0.05) in group B, while the opposite is seen in group A.