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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Methimazole-Induced Agranulocytosis in a Mother and her Young Daughter, the Possible Role of Genetic Factors in the Development of Methimazole- Induced Agranulocytosis
Authors
1Division of Endocrinology and Metabolism, Department of Medicine, Tabriz University of Medical Sciences, t.u.end.d@tbzmed.ac.ir, IR.Iran
*Corresponding Author: Division of Endocrinology and Metabolism, Department of Medicine, Tabriz University of Medical Sciences, t.u.end.d@tbzmed.ac.ir, IR.Iran. Email: t.u.end.d@tbzmed.ac.ir
Published online:Apr 30, 2006
Article type:Case Report
Received:May 24, 2005
Accepted:Dec 08, 2005
How to Cite:Bahrami A. Methimazole-Induced Agranulocytosis in a Mother and her Young Daughter, the Possible Role of Genetic Factors in the Development of Methimazole- Induced Agranulocytosis. Int J Endocrinol Metab. 2006;4(2):. doi:
Abstract
Agranulocytosis is a rare but life-threatening side effect of thionamides. Some data indicate that the susceptibility to thionamide-associated agranulocytosis in patients with Graves? disease has a genetic basis. The case histories of a mother and her daughter with Graves? disease who developed agranulocytosis with methima-zole are presented here. It seems reasonable to avoid the use of thionamide derivates in hyper-thyroid relatives of patients who have had thionamide-induced agranulocytosis.
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© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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