Comparison of Outcome in Radioiodine Induced Euthyroid and Hypothyroid Patients

2Endocrine Research Center and the Division of Cardiology, Taleghani Medical Center, Shaheed Beheshti University of Medical Sciences, Azizi@erc.ac.ir, IR.Iran

International Journal of Endocrinology and Metabolism:Vol. 3, issue 4

Published online:Oct 31, 2005

Article type:Research Article

Received:Jan 01, 2005

Accepted:Nov 01, 2005

How to Cite:Shekholeslami F, Ataie L, Hedayati M, Mehrabi Y, Azizi F. Comparison of Outcome in Radioiodine Induced Euthyroid and Hypothyroid Patients.Int J Endocrinol Metab.2005;3(4):null-null.

Abstract

The major consequence of radioiodine therapy for thyrotoxicosis is hypothyroidism and long-term precise management of hypothyroidism may be problematic. In this study, the long-term outcomes were compared in radioiodine treated euthyroid and hypothyroid patients on thyroid hormone treatment. Materials and Methods: One hundred and thirty eight patients with diffuse toxic goiter were treated with radioactive iodine. One hundred and seven patients (78%) returned for follow up visits for up to 11.5±0.8 years. Numbers of occurrences of thyroid dysfunction in each patient were recorded and a total cost of management was calculated. Results: At the end, 41 patients (38%) were still euthyroid (group 1) and 66 (62%) became hypothyroid (group 2). Serum, FT4, FT3, TSH, thyroid antibodies, lipid profile, calcium, phosphorus, and PTH were measured and bone mineral density, ECG and echocardiography were performed. There was no significant difference in age, sex, duration of symptoms and thyroid function between the 2 groups. The cost of treatment was lower in group 1 than in group 2. During 11.5 years of follow up, percentage of elevated and suppressed TSH in groups 1 and 2 were 0.02 and 20.5, p<0.001 and 7.9 and 13.4, p<0.001, respectively. At the end of 10 years, goiter rate, serum T4, T3, thyroid antibodies, lipids, Ca, P and PTH and bone mineral density and echocardiography data were not signifanctly different between two groups. However, mean serum TSH and number of TSH above 5 mU/L was greater in roup 2 than 1 (p<0.01). Conclusion: It is concluded that thyroid derangements frequently occur in patients who become hypothyroid after radioiodine therapy, while on replacement therapy.

Keywords

Full Text

Full text is available in PDF

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 month ago
Scopus by Title: 0
Last Update: 1 month ago
Scopus by Title (Ref): 0
Last Update: 1 month ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

F Shekholeslami:[PubMed][Scholar]
L Ataie:[PubMed][Scholar]
M Hedayati:[PubMed][Scholar]
Y Mehrabi:[PubMed][Scholar]
F Azizi:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

Comparison of Outcome in Radioiodine Induced Euthyroid and Hypothyroid Patients

Abstract

Full Text

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 3 days ago