Full Text
Full text is available in PDF
Background:
Ghrelin plays an important role in the regulation of food intake and body weight. It also decreases testosterone and opioid secretion.
International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
Effect of Interaction Between Testosterone and Morphine on Serum Ghrelin Concentration in Sheep Fed on Different Dietary Energy Levels
Author(s):
1Faculty of Biology Science, Shahid Beheshti University, [email protected], IR Iran
2Faculty of Physiology, Shahid Beheshti University, IR Iran
3Applied Scientific Education Institute of Jahad Keshavarzi, IR Iran
4Animal physiology, Shahid Beheshti University, IR Iran
Published online:Jun 30, 2012
Article type:Research Article
Received:Jan 20, 2012
Accepted:Apr 02, 2012
How to Cite:Jafaripour D, Khazali H, Rokni H, Alipanah H. Effect of Interaction Between Testosterone and Morphine on Serum Ghrelin Concentration in Sheep Fed on Different Dietary Energy Levels. Int J Endocrinol Metab. 2012;10(3):. doi: https://doi.org/10.5812/ijem.4211
Abstract
Objectives:
The goal of the present study was to investigate the effect of testosterone, morphine or simultaneous injection of testosterone and morphine on mean serum ghrelin concentration in sheep.
Materials and Methods:
Ten sheep were divided into two groups (n = 5 in each group), they were fed with either 50 % or 100 % of their dietary energy needs for 10 days. Body weight was measured on the 1st and 10th day of the experiment. Animals in both groups received testosterone (60 ?g/kg), morphine (0.15 mg/kg), or a simultaneous infusion of testosterone (60 ?g/kg) and morphine (0.15 mg/kg), on the 8th, 9th, or 10th day of the experiment respectively. Blood samples were collected before and 2 hours after the infusions. Ghrelin concentration was determined by RIA (radio immunoassay).
Results:
In the 50 % group, ghrelin concentrations increased significantly on the 8th day of the experiment, compared to the 1st day (P < 0.05). While in the 100 % group, no significant change was observed. In both groups the animals body weight did not increase significantly on the 10th day compared to the 1st day. Testosterone significantly increased ghrelin levels after injection compared to before infusion, in both groups (P < 0.05). Morphine increased ghrelin concentration in both groups, but this increase was not statistically significant. Simultaneous injection of testosterone and morphine together, significantly increased ghrelin concentration following injection compared to before infusion, in both groups (P < 0.05).
Conclusions:
There is a direct correlation between food restriction, testosterone and ghrelin concentration in ruminants. However, a simultaneous injection of testosterone and morphine did not exert an additive effect on ghrelin secretion.
Keywords
Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
1
Jan
2015
The Effect of Ghrelin and Estradiol on Mean Concentration of Thyroid Hormones
Fatemeh Kordi,
Homayoun Khazali
Kordi F, Khazali H. The Effect of Ghrelin and Estradiol on Mean Concentration of Thyroid Hormones. Int J Endocrinol Metab. 2015;13(1):e17988. doi: https://doi.org/10.5812/ijem.17988
25
May
2015
The Effects of Immobilization Stress on Serum Ghrelin Level, Food Intake and Body Weight in Male and Female Rats
Parvin Zareian,
Zohre Genabzadeh Jahromy,
Ahmad Mozafar
Zareian P, Genabzadeh Jahromy Z, Mozafar A. The Effects of Immobilization Stress on Serum Ghrelin Level, Food Intake and Body Weight in Male and Female Rats. J Arch Mil Med. 2015;3(2):e27167. doi: https://doi.org/10.5812/jamm.3(2)2015.27167
31
Jan
2008
Effect of Ghrelin on Plasma Concentration of Gonadotropins in the Female Sannan Goats
F Farifteh,
H Khazali,
M Emami
Farifteh F, Khazali H, Emami M. Effect of Ghrelin on Plasma Concentration of Gonadotropins in the Female Sannan Goats. Int J Endocrinol Metab. 2008;6(1):. doi:
1
Jan
2011
Effect of High Energy Intake and Treatment with Galanin on Gonadotropin Levels in Female Goats
Fateme Aboutalebi,
Mohammad Ali Emami,
Homayoun Khazali,
Mohammad Ali Emami
Aboutalebi F, Emami M, Khazali H, Emami MA. Effect of High Energy Intake and Treatment with Galanin on Gonadotropin Levels in Female Goats. Int J Endocrinol Metab. 2011;9(1):. doi: https://doi.org/10.5812/Kowsar.1726913X.1748
29
Apr
2013
Effects of morphine dependency and its abstinence on serum concentrations of sex hormones and reproductive system in male rats
Mahnaz Ghowsi,
Namdar Yousofvand,
Ali Pourmotabbed
Ghowsi M, Yousofvand N, Pourmotabbed A. Effects of morphine dependency and its abstinence on serum concentrations of sex hormones and reproductive system in male rats. J Kermanshah Univ Med Sci. 2013;17(1):e77138. doi:
Crossmark
Checking
Comments
Number of Comments:0Cited by
- Scopus by DOI: 4
Last Update: 3 days ago
- Scopus by Title: 4
Last Update: 3 days ago
- Scopus by Title (Ref): 4
Last Update: 3 days ago
- CrossRef: 4
Last Update: 4 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Search Relations
Author(s):
Related Articles