3.1. Gambling Disorder and Suicidality
A positive relationship between gambling and suicidality has been found in a number of previous studies (
13), but the results were equivocal. It is not possible to establish whether or not gambling is and how it might be responsible for individual suicide (
14). It is thought that the rates of suicide attempts and suicide are higher in pathological gamblers than that for the general population, as evidenced in research. Studies have focused mainly on gamblers seeking rehabilitation, who expressed suicidal thoughts or admitted to having attempted suicide previously (
15).
It has also been observed that pathological gamblers with suicidal thoughts, compared to other problem gamblers, reported challenges with alcohol or drug abuse, mental health, finances and relationships. The extent to which suicide ideation or attempts can be linked to gambling, as opposed to other factors, has not been established. The use of different population samples has resulted in ambiguous findings (
16).
Moran at al. (
17) conducted a study on 162 gamblers registered with Gamblers Anonymous (GA). They found that 20% of the subjects had attempted suicide and 77% had suicidal thoughts. One hundred and sixty-four GA members were included in a subsequent study by Frank et al. (
18). The results suggest that 13% of the population reported a history of suicide attempts and 48% of the population only suicidal ideation. Pathological gamblers who sought professional outpatient treatment were evaluated in other studies in the literature. These results showed that 35% - 42% of the subjects contemplated suicide and 22% - 31% reported a suicide attempt (
19-
21). Of 50 pathological male gamblers in an inpatient unit, 80% reported suicidal ideation and 12% attempted suicide (
22).
It was highlighted in a literature review by Specker et al. (
23) that 12% - 24% of suicide attempt rates were attributed to pathological gamblers (
24).
Attention is increasingly being given to gambling in recent years. Initial studies were limited by small sample numbers, resulting in newer studies being conducting on larger population samples.
It was shown in a Canadian study, the first survey to be nationally representative of the general population conducted to date, that the association between gambling disorder and attempted suicide in the past year has been significant (
25). Gambling disorder was associated with attempted suicide in the final logistic regression model, which included gambling disorder, major depression, alcohol dependence, and mental health care, as well as age, sex, education, and income, but it was not possible to establish whether or not the relation was causal.
Moghaddam et al. analyzed five gambling groups derived using the DSM-IV criteria for pathological gambling and involving 13578 individuals who participated in the National Epidemiologic Survey on alcohol and related conditions in a Californian study (
26). Pathological gambling was associated with suicidal ideation and suicide attempts after adjusting for sociodemographic variables. Thon et al. found that a suicide attempt history could be attributed to 10% of pathological gamblers in a nationwide Austrian treatment population sample (
27).
Many studies have attempted to find a possible link between the presence of casinos and the rate of completed suicides. The results remain controversial. The highest rates of completed suicides have been observed in cities where there are numerous opportunities for gambling. However, it has also been noted that there is not a corresponding increase in the number of suicides in cities in which new casinos have opened (
28).
Séguin et al. investigated two groups of individuals who had completed suicide, one with and the other without gambling problems (
29). The findings showed that the two groups were comparable in terms of psychopathology, with the exception of those with cluster B personality disorders and gambling disorder. Although both groups had tended to use mental health services less frequently in the month prior to their suicide than they had done in the previous year, this was more marked in gambling disorder with suicide.
The study by Bischof et al. was the first to analyze the role of personality disorders in suicidal behavior among pathological gamblers (
30). The results emphasized that cluster B personality disorders in which impulsivity featured strongly were especially prognostic of, and were a serious risk factor for, a suicidal event.
Petry et al. conducted a study on individuals who sought help for pathological gambling. They divided the participants into three groups based on their history of lifetime suicidality, categorized as those who had been involved in a suicidal attempt, those with the absence of suicidal thoughts, and those with suicidal ideation alone. Pathological gamblers with a previous history of suicidality reported the presence of psychiatric disturbances and more difficulties in their interpersonal relationships than those who were comparatively more emotionally stable. Most of the individuals in this group were single or unsatisfied with their marital and living arrangements. Some of the study subjects experienced a period of conflict in the month prior to the suicide attempt. There was no significant difference in age or gender between those who had attempted suicide and the other groups, but the former was found to have a more substantial treatment history for substance use disorders.
Those with suicidal ideation craved gambling intensely, were frequently bankrupt, spent more money in the month prior to the suicide attempt, and had previously undergone gambling treatment. Gamblers who participate in gambling games for which skills and knowledge are required, rather than luck, need to maintain the ability to engage in decision-making. In one study, the rate of mental distress was reported to be lower in such gamblers who were also associated with a lower suicide attempt rate (
22). Suicide attempts and bankruptcy can be predicted by a family history of addiction (
31).
Maladaptive social and emotional coping skills have been reported in the family members of gamblers with an addiction disorder. Furthermore, these coping strategies often facilitate the development of pathological gambling and result in suicide attempts and/or bankruptcy.
It has been revealed that both male and female gamblers experience depression, but that the rate of suicidal thoughts and attempts is increased in women. By contrast, men with gambling problems are at higher risk of alcohol abuse and inappropriate sexual behavior (
32).
Kausch reported an increased risk of suicide in gambling disorder subjects who abused drugs, perhaps as a result of the associated impulsivity (
19). The association between substance abuse or alcohol and gambling has been reported extensively in the literature.
It was found in a retrospective study that it was even stronger in the case of addiction to both alcohol and substances. Of the gamblers who reported a history of suicide, 73% of them had a history of substance abuse or addiction. However, it was noted that it was more common to find a history of suicide among the group of abusers than among the non-abusers (
33).
Hodgins et al. exposed the difficulty of obtaining clear data on the relationship between gambling and suicide owing to differences in study population samples (
15). Additionally, it was difficult to clearly identify co-morbidities owing to the fact that the same criteria were not applied to all of the studies. Hodgins et al. conducted a study on pathological gamblers and tried to explain the link between pathological gamblers and gambling-related suicides using a model in which common factors could be conceptualized. They suggested that certain factors, such as early onset, lack of treatment, substance use, mood disorders, and financial loss, precipitate individuals with gambling disorder and other psychiatric vulnerabilities to suicidal behavior. They considered three subsamples; subjects without suicidal ideation, subjects with a history of suicidal ideation, and those who had attempted suicide. They observed that suicide ideation often preceded the onset of pathological gambling. This confirms that suicidality is closely linked to issues of a psychopathological nature. In addition, a history of suicidal ideation seems to be linked to worsening gambling behavior. It is more probably that those with a history of suicidal ideation will develop mood disorder. It was also found that individuals who reported a suicide attempt at the time of observation had an history of substance abuse or dependence, and that this was not the case in those with a history of suicidal ideation (
15).
Wong et al. evaluated a suicide case series in a psychological autopsy study on suicides with gambling disorder (
34). Suicide related to pathological gambling in individuals who had unmanageable debts imputable to gambling in four cases. More than half had mood disorders prior to death. Financial difficulties resulting from gambling disorder might play a key role in the exacerbation of depression. Both are major causal risk factors for suicide. Gambling disorder was considered to be modifiable risk factor for suicide (
34).
In a time-series analysis of national data, Chen et al. considered a possible association between the number of suicides and the lottery sales volume in a week in Taiwan (
35). They found a positive correlation in this regard when the lottery was characterized by higher winnings, a lower probability of winning and a higher outlay. By contrast, a negative correlation was found when the lottery was characterized by lower winnings, a higher probability of winning and a lower outlay. A weekly lottery featuring a higher winning was more publicized but associated with a lower probability of winning and a higher monetary outlay, and thus loss, leading to the most ruinous financial consequences (
35).
A statistically significant odds ratio (OR) of 4.4 was reported with regard to an association between gambling disorder and suicide plans in a study by Park et al. (
12) on a randomly chosen Korean population. The presence of other psychiatric disorders which might have been involved in the suicide plans and attempts, such as depression, mood disorder, or substance abuse or dependence, were not taken into account in the analysis. The OR was no longer statistically significant when psychiatric disorders were factored in. It was concluded that gambling disorder is an independent risk factor for suicide (
12).
Wong et al. evaluated the adverse consequences of legalized gambling in public health in a study on suicide cases in Hong Kong (
13). They included three sample groups; suicides without gambling behavior, suicides with gambling behavior but no gambling-related debt, and suicides with gambling and gambling-related debt. They found that gambling behavior was prevalent among all the suicides, and that suicide in gamblers with gambling-related debts differed to that in the others. Suicide in gamblers without related debt was reported in subjects with a history of psychiatric distress. Primarily, they were recreational gamblers and gambling didn’t play had a key role in their suicides. A history of psychiatric illness was not associated with those who were indebted because of gambling. Indebtedness was highlighted as an important risk factor for suicide, especially in individuals involved with loan “sharks” or legal financial institutions prior to their deaths. A strong association was also found between a history of alcohol abuse (but not a history of drug abuse) and suicide (
13).
The major studies outlined in this paper are detailed in
Table 1.
| References | Country | Sample Size | Major Findings |
|---|
| Moran et al. (17) | | Anonymous gamblers (162) | The results showed that 77% of the subjects contemplated suicide and 20% had attempted it. |
| Frank et al. (18) | | Anonymous gamblers (164) | The results demonstrated that 48% of the subjects reported suicidal ideation only, while 13% of them reported in anamnesis suicide attempts. |
| Taber et al. (36) | Spain, Germany | | It was found that 35% - 42% of the study participants contemplated suicide and 22% - 31% reported a suicidal attempt. |
| Petry et al. (22) | | Male pathological gamblers (50) in an inpatient unit | Eighty per cent of the subjects reported suicidal ideation and 12% attempted suicide. |
| Specker et al. (23) | USA | Outpatient subjects (40) in treatment for gambling and 64 controls | The prevalence of suicide attempts ranged from 12% - 24% in pathological gamblers. |
| Seguin et al. (29) | | Pathological gambling suicides (49) and non-pathological gambling suicides (73) | The two groups were comparable in terms of psychopathology, with the exception of cluster B personality disorders and gambling disorder. Although both groups had tended to use mental health services less frequently in the month prior to their suicide than they had done in the previous year, this was more noticeable in gambling disorder suicides. |
| Petry (22) | | Participants (347) | Outpatients with anamnestic episodes of suicidality were found to frequently experience psychiatric challenges and interpersonal distress (mostly bankruptcy). Pathological gamblers and subjects without anamnestic suicidal ideation reported spending more on gambling in the month prior to commencing treatment. They craved gambling and logged high scores using the South Oaks gambling screen (a screen for compulsive gambling) |
| Kausch (19) | USA | Subjects (113) | The results showed that there was a higher risk of suicide in gambling disorder subjects involved in drug abuse than in those who did not abuse drugs, perhaps as a result of the associated impulsivity. |
| Hodgins et al. (15) | | Individuals with gambling problems (101) | Frequently, pathological gamblers have psychiatric co-morbidities (mostly mood disorders and/or substance use). It was found that economic difficulties precipitated suicidal acts. |
| Wong et al. (13) | Hong Kong, China | Suicides (150) and controls (150) | All subjects who committed suicide had extensive debt secondary to gambling, and approximately half of them had mood disorders. Economic difficulties caused by gambling increased depression. Both are major causal risk factors for suicide. |
| Chen et al. (35) | Taiwan | All suicides aged ≥ 15 years | There was a positive association between the number of suicides per week and the lottery sales volume, characterized by higher winnings, a lower probability of winning and a higher outlay. |
| Park et al. (12) | Korea | Participants (6 510) | A statistically significant odds ratio of 4.4 was reported for the association between gambling disorder and suicide plans |
| Wong et al. (34) | Hong Kong, China | Suicides (1201) recorded in Hong Kong | Gambling behavior was prevalent among suicides. Indebtedness was seen as a suicidal risk factor. |
| Newman and Thompson (25) | Canada | Subjects (36984) | The link between gambling disorder and attempted suicide was found to be significant. |
3.2. Gambling Disorder and Psychiatric Co-Morbidities
Gambling disorder is frequently found in subjects with substance use problems (
37-
39). Gamblers report higher gambling activity following the consumption of alcohol or drugs, are more psychosocially dysfunctional than patients with a single disorder (
40) and are refractory to rehabilitation (
41).
The onset of substance and/or alcohol abuse usually precedes a gambling problem. Alcohol is the most frequent substance used, followed by marijuana and cocaine. The prevalence of co-morbid alcohol abuse or dependence significantly increases by more than threefold. A high prevalence of alcohol use disorders in pathological gamblers, and gambling disorder in individuals with an alcohol use disorder, is well established in the international literature (
42).
The connection between gambling disorder and substance abuse can be explained by the addictive, impulsive, and compulsive nature of these disorders. Suicide attempts are frequent in gamblers. Addictive sexual behavior and compulsive shopping are mostly associated with gambling problems in the presence of comorbidities, such as alcohol or drug disorders, rather than in subjects with gambling disorder problems alone (
19). Thus, gamblers are susceptible to addictive, compulsive and impulsive behaviors (
20). Perhaps this can be attributed to their genetic predisposition, as supported by scientific data. Coping skill deficits in critical domains have also been observed in gamblers (
21).
It has been shown in scientific research that it is more likely that similarities in the co-morbidities in alcohol use disorder and gambling disorder will be observed in men than in women, and such co-morbidities are frequently associated with suicide attempts, daily tobacco use, drug use, and substance abuse in general, as well as a family history of alcohol and/or drug problems and legal problems consequent to gambling.
Bipolar disorder (BD) is frequently associated with gambling disorder because it is characterized by a predisposition to suicide behavior and impulsivity (
43,
44). A bipolar disorder diagnosis and impulsive conduct (such as gambling disorder, alcohol and drug use, and abuse) has been identified in more men than women according to the scientific data (
45). Lithium seems to be the only effective treatment for suicide behaviour, impulsivity, and concurrent disorders (
46), probably owing its recently established association with better decision-making in remitted bipolar patients (
47).
An interesting similarity in the co-morbidities in gambling and those in PTSD has been identified in the literature. Approximately 15% of subjects with lifetime GD met the lifetime PTSD criteria too. Thus, there is a high risk that those with an established PTSD diagnosis will become gamblers. Similarly, gambling disorder symptoms can be seen to be predictive of the subsequent onset of PTSD symptoms (
3). Common characteristics in patients with both PTSD and gambling diagnosis have been identified, including depression, anxiety, substance abuse symptoms, an avoidant personality style (
36,
48), earlier age of gambling onset (
49), greater lifetime gambling and psychiatric symptom severity, impulsivity (seen as a central trait in all addictive disorders), dissociation (
50), greater frequency of suicide attempts (
15,
51), drug and alcohol dependence (
52), and a tendency to avoid responsibility for problems (
53).
Ultimately, the core challenge is represented by trauma, which aside from PTSD, has been found to be associated with problem and/or gambling disorder, and consequently with suicidality (
54).
Borderline personality disorder is one of the most frequent personality disorders that is characterized by an important sign; the impulsivity that is present in gambling disorder and suicidality. Impulsivity is commonly assessed using the Iowa Gambling Task (IGT) (
29), a computerized assessment that assists in the evaluation of decision-making mediated by the prefrontal cortex. A characteristic pattern of impaired performance in borderline patients has been demonstrated with the use of the IGT, which is very similar to that identified in gamblers (
55).
An association has been made between gambling disorder and both major depression and suicidality, according to the findings of epidemiological studies.
Participation in online pathological gambling, Internet addiction, and offline pathological gambling appears to correlate strongly with depression. Poker players are overrepresented among online gamblers and gambling behavior tends to be more excessive on the Internet. Compared with offline gamblers, online gamblers report involvement in more co-occurring risky behavior, such as alcohol and cannabis use (
56).
In addition, gambling disorder is characterized by a variety of severely negative consequences, such as financial debt, difficulties relating to family and society, problems with employment and legality, psychological suffering (
57), child neglect, domestic violence, criminal involvement, and juvenile delinquency (
12).
The significant incidence of suicidal ideation and suicide attempts in problem gamblers seeking treatment is a clear indication that patients with gambling addiction should be evaluated for suicide risk and deliberate self-harm.