Innovative Journal of Pediatrics
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Beta Globin Frameworks in Thalassemia Major Patients from North Iran
Author(s):
1Genetic Laboratory, Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran
21. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol & Genetic Laboratory, Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran
*Corresponding Author: 1. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol & Genetic Laboratory, Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran Email: [email protected]
Published online:Sep 30, 2012
Article type:Research Article
Received:May 12, 2011
Accepted:Mar 10, 2012
How to Cite:Azizi M, Banihashemi A, Akhavan-Niaki H. Beta Globin Frameworks in Thalassemia Major Patients from North Iran. Inn J Pediatr. 2015;22(3):. doi:
Abstract
Objective: Four combinations of five neutral sequence changes at rs713040, rs10768683, rs7480526, rs7946748, and rs1609812 occurring in the human beta globin gene defined as frameworks have been reported in beta globin gene. Here we report for the frequency of these frameworks in thalassemia major patients of North Iran.
Methods: Beta globin gene frameworks of 46 thalassemia major patients of North Iran were determined using Denaturing Gradient Gel Electrophoresis.
Findings: All these frameworks called framework 1, 2, 3, 3a were present at the frequency of 23.9%, 45.7%, 6.5% and 23.9% respectively.
Conclusion: These frameworks may be used for tracking mutant alleles in prenatal diagnosis programs.
References
- 1.References are available in PDF.
Copyright
© 2015, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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