Splenectomy for Hematological Disorders in Iranian Pediatric Patients: A Single Center Study

Mona Hedayat; Nima Rezaei; Samin Alavi; Raheleh Kaviani; Mohammad Thaghi Arzanian; Bibi Shahin Shamsian

Innovative Journal of Pediatrics

The Scientific Journal of Growth & Development Research Center

Outlines

Abstract
References
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Splenectomy for Hematological Disorders in Iranian Pediatric Patients: A Single Center Study

Author(s):

Mona Hedayat¹,

Nima Rezaei²,

Samin Alavi³,

Raheleh Kaviani³,

Mohammad Thaghi Arzanian³,

Bibi Shahin Shamsian^3,*

1Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran & Molecular Immunology Research Center and Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran

2Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran & Molecular Immunology Research Center and Department of Immunology, Tehran University of Medical Sciences, Tehran, Andorra

3Department of Pediatric Hematology-Oncology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Innovative Journal of Pediatrics:Vol. 22, issue 2; 275-276

Published online:Jun 30, 2012

Article type:Letter

Received:Jan 26, 2011

Accepted:Nov 15, 2011

How to Cite:Hedayat M, Rezaei N, Alavi S, Kaviani R, Arzanian MT, et al. Splenectomy for Hematological Disorders in Iranian Pediatric Patients: A Single Center Study. Inn J Pediatr. 2015;22(2):. doi:

Abstract

Splenectomy is a widely accepted therapeutic strategy in the management of a variety of hematological disorders[1]. Regardless of its therapeutic advantages, it may be followed by overwhelming post-splenectomy infection (OPSI), the most devastating complication in asplenic individuals, which is a fulminant and rapidly fatal condition mainly due to encapsulated organisms[2]. The true incidence of OPSI is not well known; however, age at time of splenectomy, the underlying diagnosis, and the time elapsed from splenectomy constitute the main determinants of fatal outcome [3,4]. Vaccinations against Strepto¬coccus pneumoniae, Haemophilus influenzae type b, and Neisseria meningitidis, and long-term antibiotic prophylaxis, in conjunction with patient education, have been strongly advocated in splenectomized patients [2,5].
The present study was conducted to address issues related to the enforcement of and compliance with current prevention guidelines among splenectomized patients in a tertiary care setting. In a retrospective cross-sectional study, we evaluated 53 patients aged 1.5 to 23 years (32 males and 21 females) undergoing splenectomy within a 5-year period at Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran. The most common indications for splenectomy were thalassemia major (43.3%), hereditary spherocytosis (HS) (15.1%), and idiopathic thrombocytopenic purpura (ITP) (11.3%). Findings from other studies indicated that ITP[6,7], sickle cell disease[8,9], and HS[10] were the most common single hematologic disorders requiring elective splenectomy in the course of the disease. The noted discrepancy might be partially due to the fact that beta-thalassemia is particularly prevalent among the Mediterranean countries, justifying its high prevalence among Iranian patients undergoing splenectomy.
Studies conducting retrospective audits of vaccination status in splenectomized individuals reported 62-80.6% vaccination rate against Streptococcus pneumonia [11-13], whereas in the present study, all 53 patients (100%) received pneumococcal vaccination perioperatively, with 41.5% and 35.8% of them being respectively vaccinated against Neisseria meningitidis and Haemophilus influenzae type b as well. On the whole, 58.5% received all three vaccines.
Of all studied patients, 38 (71.7%) were provided with follow-up care, of whom, 4 developed OPSI and died at the time of study. A review of available follow-up data revealed that 33 (out of 34) patients were receiving daily prophylactic oral penicillin, compared to 63-93 % of patients being prescribed long-term antibiotic prophylaxis in other studies [13-15].
Besides appropriate and timely immunization with pneumococcal vaccine and a high compliance rate to daily antibiotic prophylaxis, adherence to the remaining key guidelines concerning proper immunization against Haemophilus influenzae and Neisseria meningitidis and, more important, patient education, i.e. providing patients with clear discharge instructions emphasizing on the importance of timely follow-up visits and recognizing the need for urgent referral for any suspected infection, is not fully satisfying. Many of these could be met affordably by developing a registry of splenectomized patients, which will be aiding in providing patients with continued follow-up cares.

Keywords

Splenectomy

Pneumococcal Vaccines

Sepsis

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References

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References are available in PDF.

Bacterial Etiology of Fever Episodes of Splenectomized Patients in Three Medical Centers in the City of Mashhad in Northeastern Iran

Mahnaz Arian,

Azade Haji Moniri,

Mona Najaf Najafi,

Bahareh Imani,

Mohammad Afkar,

Jalil Hasani

Arian M, Haji Moniri A, Najaf Najafi M, Imani B, Afkar M, et al. Bacterial Etiology of Fever Episodes of Splenectomized Patients in Three Medical Centers in the City of Mashhad in Northeastern Iran. Arch Clin Infect Dis. 2022;17(1):e110883. doi: https://doi.org/10.5812/archcid-110883

25

May

2010

The incidence of complications of vaccination in children and infants of Semnan, Iran

Mohammad Nabovi,

Jafar Jandaghi,

Mohammad KhaleghiHashemian,

Hoda Shojaei,

Saba MaherBanaei,

Farzaneh MohammadZadeh

,et al.

Nabovi M, Jandaghi J, KhaleghiHashemian M, Shojaei H, MaherBanaei S, et al. The incidence of complications of vaccination in children and infants of Semnan, Iran. koomesh. 2010;11(4):e152294. doi:

18

Jan

2023

Anesthetic Management of a Patient with Reactive Thrombocytosis due to Post-Trauma Splenectomy in a Patient Requiring Further Corrective Surgeries: A Case Report

Soumily Bandyopadhyay,

Abhishek Singh,

Babita Gupta

Bandyopadhyay S, Singh A, Gupta B. Anesthetic Management of a Patient with Reactive Thrombocytosis due to Post-Trauma Splenectomy in a Patient Requiring Further Corrective Surgeries: A Case Report. J Cell Mol Anesth. 2023;8(3):e149692. doi: https://doi.org/10.22037/jcma.v8i3.39601

24

Jan

2015

Adult Immunization Among Health Care Personnel and Target Groups in Iran

Shervin Shokouhi,

Ilad Alavi Darazam,

Golsa Kardan

Shokouhi S, Alavi Darazam I, Kardan G. Adult Immunization Among Health Care Personnel and Target Groups in Iran. Arch Clin Infect Dis. 2015;10(1):e24714. doi: https://doi.org/10.5812/archcid.24714

1

Apr

2008

Spleen-Preserving Surgery Versus Splenectomy for Splenic Hydatid Cyst: Ten Years Experience

Sh Rahmani,

Arash [email protected]

Rahmani S, [email protected] A. Spleen-Preserving Surgery Versus Splenectomy for Splenic Hydatid Cyst: Ten Years Experience. Shiraz E-Med J. 2008;9(2):e93736. doi:

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Author(s):

Mona Hedayat:[PubMed][Scholar]
Nima Rezaei:[PubMed][Scholar]
Samin Alavi:[PubMed][Scholar]
Raheleh Kaviani:[PubMed][Scholar]
Mohammad Thaghi Arzanian:[PubMed][Scholar]
Bibi Shahin Shamsian:[PubMed][Scholar]

The Scientific Journal of Growth & Development Research Center

Outlines

Splenectomy for Hematological Disorders in Iranian Pediatric Patients: A Single Center Study

Abstract

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References

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