Fulltext
Full text is available in the PDF.
IJ Psychiatry and Behavioral Sciences
IJPBS is the Official Journal of Mazandaran University of Medical Sciences
Outlines
Comparing the Efficacy of add-on Nortryptiline With Triiodothyronine in the Management of Citalopram-Resistant Depression
Author(s):
1Assistant professor of Psychiatry. Fellowship of neuropsychiatry, Mashad University of Medical Sciences, Avicenna Hospital, Mashad, Iran
2Department of Psychiatry Mashad University of Medical Sciences, Iran
*Corresponding Author: Assistant professor of Psychiatry. Fellowship of neuropsychiatry, Mashad University of Medical Sciences, Avicenna Hospital, Mashad, Iran Email: [email protected]
Published online:Jul 30, 2007
Article type:Research Article
Received:May 25, 2007
Accepted:Jun 15, 2007
How to Cite:Mokhber N, Talaei A. Comparing the Efficacy of add-on Nortryptiline With Triiodothyronine in the Management of Citalopram-Resistant Depression. Iran J Psychiatry Behav Sci. 2007;1(2):. doi:
Abstract
Objective: To manage a treatment resistant depression, clinicians may add a second medication to the first antidepressant drug. The aim of the current research was to study the outcome of augmentation of citalopram with nortryptiline or triiodothyronine in a randomized clinical trial.
Methods: We selected 48 adult outpatients with a diagnosis of non-psychotic major depressive disorder who had not responded to 12 weeks citalopram therapy (40 mg per day). They were randomly allocated to two groups. One group received nortryiptiline (at a dose of up to 150 mg per day) and the other triiodothyronine (T3) (at a dose of up to 50 µg per day). The remission of depression was defined as a score of 7 or less on the 17-item Hamilton Rating Scale for Depression (HRSD-17).
Results: After 8 weeks, the nortriptyline group had a higher remission rate (33.33 %) than the triiodothyronine group (17.64%). The nortriptyline group, however, had a higher dropout rate due to experiencing more side effects
Conclusion: Augmentation of citalopram with nortryptiline seems to be effective in the management of treatment resistant depression. However, one should strike a balance between the efficacy and the tolerability of this approach, as there is a higher chance of experiencing side effects by the patients.
References
- 1.References are available in the PDF.
Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
1
Jun
2015
Double-Blind Randomized Clinical Trial of the Efficacy of Venlafaxine Versus Citalopram in the Treatment of the Acute Phase of Major Depressive Disorder
Fatemeh Hosseini,
Fariba Amini,
Seyed Mojtaba Yassini Ardekani,
Neda Shariat,
Mohammad Nadi
Hosseini F, Amini F, Yassini Ardekani SM, Shariat N, Nadi M. Double-Blind Randomized Clinical Trial of the Efficacy of Venlafaxine Versus Citalopram in the Treatment of the Acute Phase of Major Depressive Disorder. Iran J Psychiatry Behav Sci. 2015;9(2):-. doi: https://doi.org/10.17795/ijpbs1041
23
Jun
2015
Comparing the Efficacy of 8 Weeks Treatment of Cipram® and its Generic Citalopram in Patients With Mixed Anxiety-Depressive Disorder
Hasan Khoonsari,
Mohammad Bagher Oghazian,
Mona Kargar,
Mahdiyeh Moin,
Hossein Khalili,
Abbas Alimadadi
,et al.Khoonsari H, Oghazian MB, Kargar M, Moin M, Khalili H, et al. Comparing the Efficacy of 8 Weeks Treatment of Cipram® and its Generic Citalopram in Patients With Mixed Anxiety-Depressive Disorder. Iran J Psychiatry Behav Sci. 2015;9(2):-. doi: https://doi.org/10.17795/ijpbs230
30
Jun
2011
Major Depressive Disorder: A Comparison of a Focused Psychodynamic Psychotherapy and Pharmacotherapy
Fateh Rahmani,
Farzin Rezaei,
Marzie Nasuri
Rahmani F, Rezaei F, Nasuri M. Major Depressive Disorder: A Comparison of a Focused Psychodynamic Psychotherapy and Pharmacotherapy. Iran J Psychiatry Behav Sci. 2011;5(1):. doi:
19
Sep
2023
The Effects of Remifentanil, Dexmedetomidine, and Metoral as Adjuncts to Thiopental on Hemodynamic Status After Electroconvulsive Therapy in Patients with Major Depressive Disorder: A Randomized Controlled Clinical Trial
Nastaran Tajabadi,
Alireza Kamali,
Anita Alaghmand,
Hamidreza Jamilian,
Shirin Pazooki,
Amin Tajerian
Tajabadi N, Kamali A, Alaghmand A, Jamilian H, Pazooki S, et al. The Effects of Remifentanil, Dexmedetomidine, and Metoral as Adjuncts to Thiopental on Hemodynamic Status After Electroconvulsive Therapy in Patients with Major Depressive Disorder: A Randomized Controlled Clinical Trial. Anesth Pain Med. 2023;13(5):e139383. doi: https://doi.org/10.5812/aapm-139383
22
Jan
2014
The Comparison of the Effectiveness of Thiothixene and Risperidone as a Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder
Shahrzad Mazhari,
Hasan Ziaadini,
Nooshin Parvaresh,
Maryam Fazli
Mazhari S, Ziaadini H, Parvaresh N, Fazli M. The Comparison of the Effectiveness of Thiothixene and Risperidone as a Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder. Zahedan J Res Med Sci. 2014;16(10(suppl)):. doi:
Download PDF112.42 KB
Comments
Number of Comments:0Cited by
- Scopus by DOI: 0
Last Update: 0 months ago
- Scopus by Title: 0
Last Update: 0 months ago
- Scopus by Title (Ref): 0
Last Update: 0 months ago
- CrossRef: 0
Last Update: 4 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Search Relations
Related Articles