The Comparison of the Effectiveness  of Thiothixene and Risperidone as a  Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder

Shahrzad Mazhari; Hasan Ziaadini; Nooshin Parvaresh; Maryam Fazli

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

The Comparison of the Effectiveness of Thiothixene and Risperidone as a Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder

Author(s):

Shahrzad Mazhari¹,

Hasan Ziaadini²,

Nooshin Parvaresh²,

Maryam Fazli^3,*

2Department of Psychiatry, Kerman Univer sity of Medical Sciences, Kerman, Iran

2Kerman Neuroscience Research Center, Department of Psychi atry, Kerman University of Medical Sciences, Kerman, Iran

3Resident of Psychiatry, Kerman University of Medical Sciences, Kerman, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 16, issue 10(suppl)

Published online:Jan 22, 2014

Article type:Research Article

Received:Feb 28, 2013

Accepted:May 01, 2013

How to Cite:Mazhari S, Ziaadini H, Parvaresh N, Fazli M. The Comparison of the Effectiveness of Thiothixene and Risperidone as a Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder. Zahedan J Res Med Sci. 2014;16(10(suppl)):. doi:

Abstract

Background: The effectiveness of various atypical antipsychotics in the treatment of acute mania is reported repeatedly, but those for typical antipsychotics are restricted to haloperidol and chlorpromazine. As there is a comparative importance of side effects for typical and atypical antipsychotics, we decided to compare the therapeutic effect of thiothixene and risperidone as a combination with lithium for the treatment of patients with bipolar disorder.

Materials and Methods: In 8 week double-blind clinical trial, 84 patients with a diagnosis of bipolar disorder were randomized for treatment with lithium plus thiothixene (N=42) or lithium plus risperidone (N=42). Manic, positive-negative symptoms, anxiety and depression were measured bi-weekly with Young Mania Rating, positive and negative symptom scale (PANSS) and Hamilton rating scale score. Fasting blood sugar, weight, general side effects and extrapyramidal symptoms were also evaluated. The measures analyzed using SPSS-17 software. To compare demographic characteristics t-test, χ2 test and fixed effects method were used. A fixed effects method was applied to omit missing data effects.

Results: There was no significant difference between the thiothixene and risperidone groups in Young mania rating scale and other outcome measures during the 8 week trial. There was no significant difference in weight, blood sugar and clinical global impression (CGI) between groups.

Conclusion: Thiothixene is as effective as risperidone in the improvement of manic and sychotic symptoms. There was no significant difference with risperidone in developing extrapyramidal symptoms, so it can be used as an appropriate combination with lithium for the treatment of bipolar patients in psychotic manic episode.

Keywords

Fulltext

Fulltext is availale in the PDF.

References

1.
Refrences are available in PDF.

Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Mania or Mixed Feature Bipolar I Disorder: A Randomized Double-Blind Clinical Trial Study

Mercedeh Samiei,

Zahra Sepehrifar,

Reza Daneshmand,

Gita Sadighi

Samiei M, Sepehrifar Z, Daneshmand R, Sadighi G. Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Mania or Mixed Feature Bipolar I Disorder: A Randomized Double-Blind Clinical Trial Study. Iran J Psychiatry Behav Sci. 2021;15(2):e90106. doi: https://doi.org/10.5812/ijpbs.90106

30

Jan

2007

Sodium Valproate as an Adjunctive Drug in Treatment of Schizophrenia

Victoria Omranifard,

Afsaneh Karbasi Amel,

Siamak Amanat

Omranifard V, Karbasi Amel A, Amanat S. Sodium Valproate as an Adjunctive Drug in Treatment of Schizophrenia. Iran J Psychiatry Behav Sci. 2007;1(1):. doi:

30

Dec

2013

Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania

Zahra Mirsepassi,

Robabeh Mazinani,

Farbod Fadai,

Neda Alibeigi,

Ali Nazeri-Astaneh

Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania. Iran J Psychiatry Behav Sci. 2013;7(2):. doi:

26

Jan

2026

Effects of Clozapine Add-On to Risperidone vs. Risperidone Monotherapy on Agitation in Paranoid Schizophrenia: A Quasi-experimental Pilot Study

Najmiatul Fitria,

Hidayatul Arief,

Yelly Oktavia Sari,

Syofyan Syofyan

Fitria N, Arief H, Oktavia Sari Y, Syofyan S. Effects of Clozapine Add-On to Risperidone vs. Risperidone Monotherapy on Agitation in Paranoid Schizophrenia: A Quasi-experimental Pilot Study. Iran J Psychiatry Behav Sci. 2026;20(1):e164189. doi: https://doi.org/10.5812/ijpbs-164189

30

Jan

2007

Comparative Study of Clozapine, Electroconvulsive Therapy (ECT), and the Combination of ECT with Clozapine in Treatment-Resistant SchizophrenicPatients

Abbas Masoudzadeh,

Alireza Khalilian,

Seyed Hamzeh Hosseini

Masoudzadeh A, Khalilian A, Hosseini SH. Comparative Study of Clozapine, Electroconvulsive Therapy (ECT), and the Combination of ECT with Clozapine in Treatment-Resistant SchizophrenicPatients. Iran J Psychiatry Behav Sci. 2007;1(1):. doi:

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 7 hours ago
Scopus by Title: 0
Last Update: 7 hours ago
Scopus by Title (Ref): 0
Last Update: 7 hours ago
CrossRef: 0
Last Update: 4 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Shahrzad Mazhari:[PubMed][Scholar]
Hasan Ziaadini:[PubMed][Scholar]
Nooshin Parvaresh:[PubMed][Scholar]
Maryam Fazli:[PubMed][Scholar]

The Official Journal of Zahedan University of Medical Sciences

Outlines

The Comparison of the Effectiveness of Thiothixene and Risperidone as a Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder

Abstract

Fulltext

References

Similar Articles

Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Mania or Mixed Feature Bipolar I Disorder: A Randomized Double-Blind Clinical Trial Study

Sodium Valproate as an Adjunctive Drug in Treatment of Schizophrenia

Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania

Effects of Clozapine Add-On to Risperidone vs. Risperidone Monotherapy on Agitation in Paranoid Schizophrenia: A Quasi-experimental Pilot Study

Comparative Study of Clozapine, Electroconvulsive Therapy (ECT), and the Combination of ECT with Clozapine in Treatment-Resistant SchizophrenicPatients

Last Update: 7 hours ago

Last Update: 7 hours ago

Last Update: 7 hours ago

Last Update: 4 days ago