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IJ Psychiatry and Behavioral Sciences
IJPBS is the Official Journal of Mazandaran University of Medical Sciences
e-ISSN 1735-9287
p-ISSN 1735-8639
Image Credit:Iran J Psychiatry Behav Sci
Outline
Fragile X Mental Retardation Protein is Reduced in Cerebella of Subjects with Autism
Authors
1Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, MN 55455 USA, Minneapolis, United States
2Departments of Pharmacology and Neuroscience, University of Minnesota Medical School, Minnesota, United States
*Corresponding Author: Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, MN 55455 USA, Minneapolis, United States, Tel: 612-6263633, Fax: 612-6248935 Email: fatem002@umn.edu
Published online:Dec 31, 2010
Article type:Brief Report
Received:Aug 13, 2010
Accepted:Aug 24, 2010
How to Cite:Fatemi SH, D Folsom T. Fragile X Mental Retardation Protein is Reduced in Cerebella of Subjects with Autism. Iran J Psychiatry Behav Sci. 2010;4(2):. doi:
Abstract
Autism and fragile X syndrome have multiple behavioral phenotypes in common, however there has been little research into the potential role of fragile X mental retardation protein (FMRP) in autism. We sought to measure protein levels of FMRP in the lateral cerebella of subjects with autism and matched controls. We found significantly reduced levels of FMRP (p<0.0063) in subjects with autism. The loss of FMRP expression in subjects with autism may help explain behavioral deficits, presence of seizure, and reduction in GABA receptors in subjects with autism.
Declaration of interest: None
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Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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