OpenAlex

Crocin: A fighter against inflammation and pain

Food and Chemical Toxicology 143 (2020)

Mahmoud Hashemzaei; Charalampos Mamoulakis; Konstantinos Tsarouhas; George Georgiadis; George Lazopoulos; Aristidis Michael Tsatsakis; Elham Shojaei Asrami; Ramin Rezaee

Saffron: A potential drug-supplement for severe acute respiratory syndrome coronavirus (COVID) management

Heliyon 7(5) (2021)

Amjad Masood Husaini; Khan Nadiya Jan; Gowher A. Wani

Crocin molecular signaling pathways at a glance: A comprehensive review

Phytotherapy Research 36(10) (2022)

Motahareh Boozari; Hossein Hosseinzadeh

The effect of acute crocin on behavioral changes and BDNF expression level in socially isolated rats

Naunyn-Schmiedeberg s Archives of Pharmacology 397(6) (2023)

Amir-Kamyar Kamaei; Seyedeh-Fatemeh Hosseini; Parisa Teimourparsaei; Masoumeh Payamani; Salar Vaseghi

Quercetin as a Multi‐Target Natural Therapeutic in Aging‐Related Diseases: Systemic Molecular and Cellular Mechanisms

Phytotherapy Research 39(10) (2025)

Shengxue Zhou; Xinshang Qingman; Wei Zhang; Dahui Zhang; Shuang Liu

Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of male Wistar rats

Journal of Psychopharmacology 35(6) (2021)

Malihe Looti Bashiyan; Mohammad Nasehi; Salar Vaseghi; Solmaz Khalifeh

Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review

Neurochemical Research 45(11) (2020)

Sareh Kermanshahi; Ghazal Ghanavati; Mobina Abbasi Mesrabadi; Mina Gholami; Luis Ulloa; Majid Motaghinejad; Sepideh Safari

Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK

Saudi Journal of Biological Sciences 27(5) (2020)

Mardi Mohamed Algandaby

Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage

Frontiers in Pharmacology 13 (2022)

Dongming Guo; Xinlei Huang; Tianqing Xiong; Xingyi Wang; Jingwen Zhang; Yingge Wang; Jingyan Liang

Neuroprotective activity of green synthesized silver nanoparticles against methamphetamine-induced cell death in human neuroblastoma SH-SY5Y cells

Scientific Reports 13(1) (2023)

Sadegh Khorrami; Manijeh Dogani; Saeed Esmaeili‐Mahani; Mehrdad Moosazadeh Moghaddam; Ramezan Ali Taheri

Saffron (Crocus sativus L.) extract attenuates chronic scopolamine-induced cognitive impairment, amyloid beta, and neurofibrillary tangles accumulation in rats

Journal of Ethnopharmacology 326 (2024)

Komal Patel; Abhay T. Dharamsi; Madhu Priya; Sanskar Jain; Vishal Mandal; Aboli Girme; Siddharth J. Modi; Lal Hingorani

Neuroprotective and neuro-survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and mitochondrial uncoupling protein −2(UCP-2)

Medical Hypotheses 143 (2020)

Afrah Sepehr; Fereshteh Taheri; Sara Heidarian; Majid Motaghinejad; Sepideh Safari

Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide in rats.

PubMed 11(1) (2021)

Mohammad Javad Azmand; Ziba Rajaei

Therapeutic implications of crocin in Parkinson's disease: A review of preclinical research

Chemical Biology & Drug Design 101(6) (2023)

Ahsas Goyal; Aanchal Verma; Anant Agrawal; Nandini Dubey; Abhay Kumar; Tapan Behl

Advances on the anti-tumor mechanisms of the carotenoid Crocin

PeerJ 11 (2023)

Xingxun Bao; Jinhua Hu; Yan Zhao; Ruixue Jia; Hairong Zhang; Lei Xia

Erythropoietin improve spatial memory impairment following methamphetamine neurotoxicity by inhibition of apoptosis, oxidative stress and neuroinflammation in CA1 area of hippocampus

Journal of Chemical Neuroanatomy 124 (2022)

Behzad Garmabi; Reza Mohaddes; Fatemeh Rezvani; Fahimeh Mohseni; Hossein Khastar; Mehdi Khaksari

Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis

Frontiers in Pharmacology 12 (2022)

Yiwei Zeng; Yunhui Chen; Su Zhang; Huan Ren; Jialin Xia; Mengnan Liu; Baozhi Shan; Yulan Ren

Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway

Neurochemical Research 47(10) (2022)

Yan Wang; Sixu Zhou; Xujiao Song; Shanshan Ding; Baogui Wang; Jiangfeng Wen; Chunlin Chen

Modulating effects of crocin on lipids and lipoproteins: Mechanisms and potential benefits

Heliyon 10(7) (2024)

Habib Yaribeygi; Mina Maleki; Farin Rashid-Farrokhi; Payman Raise‐Abdullahi; Mohammad Amin Hemmati; Tannaz Jamialahmadi; Amirhossein Sahebkar

Crocin Improves Cognitive Impairment in LPS-treated Rats through Anti-Apoptotic, Anti-Inflammatory, and Antioxidant Activities

Molecular Neurobiology 62(5) (2024)

Maryam Dastan; Ziba Rajaei; Mohammadreza Sharifi; Hossein Salehi

Repurposing of natural products for spinocerebellar ataxia type 3 using integrated network pharmacology and in silico approaches

Scientific Reports 16(1) (2026)

Miah Roney; Nur Shahirah Mohd Hisam; Md. Nazim Uddin; S. M. Istiaque Hamim; Lee Wei Lim; Kah-Hui Wong

Methamphetamine exposure modulated oxidative status and altered the reproductive output in Daphnia magna

The Science of The Total Environment 721 (2020)

Beatrice De Felice; Simona Mondellini; Noelia Salgueiro‐González; Sara Castiglioni; Marco Parolini

NUPR1- CHOP experssion, autophagosome formation and apoptosis in the postmortem striatum of chronic methamphetamine user

Journal of Chemical Neuroanatomy 114 (2021)

Fatemeh Sadat Tabatabaei Mirakabad; Maryam Sadat Khoramgah; Mohammad‐Amin Abdollahifar; Atefeh Shirazi Tehrani; Mostafa Rezaei–Tavirani; Somayeh Niknazar; Foozhan Tahmasebinia; Gholam‐Reza Mahmoudiasl; Shahrokh Khoshsirat; Hojjat‐Allah Abbaszadeh

Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats

Brain Research 1754 (2021)

Mohadeseh Ghalandari-Shamami; Shahla Nourizade; Mehdi Barati; Behpour Yousefi; Mehrnush Pashayi; Abbas Ali Vafaei; Parviz Kokhaei; Ali Rashidy‐Pour

Crocin has a greater therapeutic role in the restoration of behavioral impairments caused by maternal social isolation in adolescent than in adult offspring probably through GSK-3beta downregulation

Learning and Motivation 88 (2024)

Hanie Karimi; Marjan Mohamadian; Paniz Azizi; Pouya Ghasemi; Mokhtar Karimi; Tannaz Layegh; Majid Rahmatkhah-Yazdi; Salar Vaseghi

Preventive effects of crocin, a natural compound from saffron, against nicotine‑induced oxidative stress and neurobehavioral disturbances

Acta Neurobiologiae Experimentalis 84(1) (2024)

Majid Motaghinejad; Manijeh Motevalian; Antoni Sureda

Antidepressive synergism between crocin and D-AP5 in acute restraint-stressed mice

Behavioural Pharmacology 35(6) (2024)

Sana-sadat Gerami; Mohaddeseh Ebrahimi-Ghiri; Fatemeh Khakpai; Mohammad‐Reza Zarrindast

Association of Crocus sativus with Cognitive Dysfunctions and Alzheimer’s Disease: A Systematic Review

Biointerface Research in Applied Chemistry 11(1) (2020)

Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?

Journal of Clinical Medicine 10(21) (2021)

José A. Fernández‐Albarral; Miguel A. Martínez‐López; Eva María Marco; Rosa de Hoz; Beatriz Martín‐Sánchez; Diego San Felipe; Elena Salobrar‐García; Inés López‐Cuenca; Maria Dolores Pinazo-Duran; Juan Jose Salazar; Jose Manuel Ramirez; Meritxell López‐Gallardo; Ana Isabel Ramirez

Calcium Channel Blockade Ameliorates Endoplasmic Reticulum Stress in the Hippocampus Induced by Amyloidopathy in the Entorhinal Cortex.

PubMed 18(3) (2019)

Azam Ghanbari-Maman; Forouzan Ghasemian-Roudsari; Shayan Aliakbari; Hamid Gholami Pourbadie; Fariba Khodagholi; Fatemeh Shaerzadeh; Mahtab Daftari

Chemopreventive role of Tin oxide-Chitosan-Polyethylene glycol-Crocin nanocomposites against Lung cancer: An in vitro and in vivo approach

Process Biochemistry 120 (2022)

Vidya Devanathadesikan Seshadri; Atif Abdulwahab A. Oyouni; Yousef MohammedRabaa Hawsawi; Saad Ali S. Aljohani; Osama M. Al‐Amer; Waseem AlZamzami; Ahmad H. Mufti

Resveratrol ameliorates the behavioural and molecular changes in rats exposed to uninephrectomy: role of hippocampal SIRT1, BDNF and AChE

Journal of Physiology and Biochemistry 79(2) (2022)

Marianne Basta; Samar R. Saleh; Rania Gaber Mohamed Aly; Abeer E. Dief

Neuroprotective Effects of Selegiline Agent Methamphetamine-Prompted Mood-Related Behavior Disorder Mediated via 5-HT2 and D2 Receptors

International Journal of Preventive Medicine 14(1) (2023)

Mina Gholami; Neda Kaviani; Majid Motaghinejad; Luis Ulloa

Preventive Effects of Crocin, a Key Carotenoid Component in Saffron, Against Nicotine-Triggered Neurodegeneration in Rat Hippocampus: Possible Role of Autophagy and Apoptosis

International Journal of Preventive Medicine 15 (2024)

Mina Gholami; Daniel J. Klionsky; Majid Motaghinejad

The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and superoxide dismutase in the hippocampus

Metabolic Brain Disease 38(4) (2023)

Saba Mehrabanifar; Saeed Hesami-Tackallou; Salar Vaseghi; Mohammad Nasehi

The Effect of Chronic Administration of Amphetamine-Type Stimulants on Oxidative Stress and Inflammation in Wistar Rats

Baghdad Science Journal 21(7) (2023)

Vita Camellia; Fasihah Irfani Fitri; Muhammad Ichwan; Dina Keumala Sari; Elmeida Effendy; Aldy Safruddin Rambe; Syafruddin Ilyas; Juliandi; Alfi Khatib; Mustafa M. Amin; Muhammad Rusda

Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression

Oncology Letters 21(1) (2020)

Minqing Zhang; Yiping Du; Jingmei Shang; Dongqing Zhang; Xiaoqing Dong; Hong Chen

Crocin lessens desipramine-induced phospholipidosis biomarker levels via targeting oxidative stress- related PI3K/Akt/mTOR signaling pathways in the rat liver.

Acta bio-medica dell'Ateneo parmense/Acta biomedica 94(2) (2023)

Amal Ahmed El-Sheikh; Heba A. Mahmoud; Eman Ali Elkordy; Amal M. Abdelsattar; Fatma H. Rizk; Radwa Mahmoud Elsharaby; Shimaa S Mashal; Amira A. El Saadany; Rania H. Shalaby; Amira Mostafa Elshamy; Omnia Safwat El‐Deeb; Rowida Raafat Ibrahim; Hoda Ali Ibrahim

Physiological and Cellular Targets of Neurotrophic Anxiolytic Phytochemicals in Food and Dietary Supplements

IntechOpen eBooks (2021)

Benjamin S. Weeks; Samuel D. Weeks; Amanda J. H. Kim; Landon Kessler; Pedro P. Perez

Examining the Cardioprotective Effects of Aerobic Exercise Combined with Crocin or Berberine on Methamphetamine-Induced Heart Damage in Female Rats

international journal high risk behaviors & addiction 13(3) (2024)

Sayed Javad Ziaolhagh; Somayeh Rajabi; Zahra Nosrati

Comparing the Efficacy of Escitalopram with and without Crocin in Restoring I/O Functions and LTP within the Hippocampal CA1 Region of Stressed Rats

Advanced Biomedical Research 13(1) (2024)

Mehran Joodaki; Maryam Radahmadi; Hojjatallah Alaei

Crocin alleviates neuronal arborization damage in the basolateral nucleus of the amygdala and dentate gyrus of the hippocampus in a stressed rat

IBRO Neuroscience Reports 19 (2025)

Milagros Barzi; Bahman Jalali Kondori; Gholam Hossein Meftahi

Effects of Crocin Supplementation on Clinical Symptoms, Cognitive Function and Psychological Status in Methamphetamine Users: A Randomized Controlled Trial

Jundishapur Journal of Natural Pharmaceutical Products 21(2) (2026)

Morteza Zamani Asadolah‐poor‐kashi; Hamid Reza Banafshe; Mehrdad Simani; Fatemeh Sadat Ghoreishi; Zahra Zanjani; Amir Ghaderi