Invitro Release Study of Sodium Salicylate from Lecithin Based Phospholipid Microemulsions

How to Cite:Aboofazeli R, Mortazavi SA, Khoshnevis P. Invitro Release Study of Sodium Salicylate from Lecithin Based Phospholipid Microemulsions. Iran J Pharm Res. 2022;2(2):e127618. doi: https://doi.org/10.22037/ijpr.2010.19

Abstract

Sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. The effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. In this investigation, two commercially available lecithins (namely Epikuron 200 and Epikuron 170), three short chain alcohols (n-butanol, isopropanol and n-propanol) and isopropyl myristate (IPM) were used as surfactant, cosurfactant and oil, respectively. The water phase was composed of sodium salicylate solution (2% w/v). To investigate the release profile, samples with 25% wt% total surfactant content were prepared with different surfactant/cosurfactant weight ratios (K_m of 1:1 and 1.5:1) and various amounts of drug solution (from 7 to 35 wt%), depending on the nature of alcohol. Two compartment Franz diffusion cells, equipped with rat skin as the absorption membrane, were employed for release studies. All experiments were performed at room temperature and sampling was taken over 12 hours with one-hour intervals. The amount of drug released was determined spectrophotometrically and the permeation parameters were then calculated. Results showed that systems formulated with 7 and 9% drug solution, were not capable of releasing the drug with a lower rate, compared to the corresponding drug solutions, while in other systems, a lower release rate was observed in comparison to the control samples. In general, among the systems investigated, those prepared with n-propanol at K_m of 1.5:1 and 11-20 wt% and 29% dispersed phase showed a relatively lower absorption rate, comparing to the corresponding control samples , regardless of the nature of surfactant and cosurfactant. Under passive conditions, the flux from microemulsions followed the zero order behavior with respect to the donor concentration.

Keywords

Preparation, Characterization, and Skin Permeation Evaluation of Naproxen Microemulsions for Transdermal Delivery

Nasibeh Jamali,

Eskandar Moghimipour,

Najmeh Hedayatipour,

Anayatollah Salimi

Jamali N, Moghimipour E, Hedayatipour N, Salimi A. Preparation, Characterization, and Skin Permeation Evaluation of Naproxen Microemulsions for Transdermal Delivery. Jundishapur J Nat Pharm Prod. 2024;19(3):e145137. doi: https://doi.org/10.5812/jjnpp-145137

28

Mar

2024

Development and Ex-Vivo Skin Permeation of Sildenafil Citrate Microemulsion System for Transdermal Delivery

Nasibeh Jamali,

Eskandar Moghimipour,

Fatemeh Nikpour,

Anayatollah Salimi

Jamali N, Moghimipour E, Nikpour F, Salimi A. Development and Ex-Vivo Skin Permeation of Sildenafil Citrate Microemulsion System for Transdermal Delivery. Iran J Pharm Res. 2024;23(1):e139381. doi: https://doi.org/10.5812/ijpr-139381

12

Jan

2022

Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels

Mahshid Daryab,

Mehrdad Faizi,

Arash Mahboubi,

Reza Aboofazeli

Daryab M, Faizi M, Mahboubi A, Aboofazeli R. Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels. Iran J Pharm Res. 2022;21(1):e123787. doi: https://doi.org/10.5812/ijpr.123787

31

Jan

2010

Preparation and Evaluation of Aceclofenac Topical Microemulsion

Rohit Ramesh Shah,

Chandrakant Shripal Magdum,

Shitalkumar Shivagonda Patil,

Nilofar Shanawaj Niakwade

Ramesh Shah R, Shripal Magdum C, Shivagonda Patil S, Shanawaj Niakwade N. Preparation and Evaluation of Aceclofenac Topical Microemulsion. Iran J Pharm Res. 2010;9(1):e126027. doi: https://doi.org/10.22037/ijpr.2010.829

1

Dec

2018

Transdermal Delivery of Ketorolac Tromethamine Using Microemulsion Vehicles

Anayatollah Salimi,

Shadi Jafarinezhad,

Azin Kalantari

Salimi A, Jafarinezhad S, Kalantari A. Transdermal Delivery of Ketorolac Tromethamine Using Microemulsion Vehicles. Jundishapur J Nat Pharm Prod. 2018;13(4):e69056. doi: https://doi.org/10.5812/jjnpp.69056

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 4
Last Update: 2 weeks ago
Scopus by Title: 4
Last Update: 2 weeks ago
Scopus by Title (Ref): 0
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 1 day ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Reza Aboofazeli:[PubMed][Scholar]
Seyed Alireza Mortazavi:[PubMed][Scholar]
Pooneh Khoshnevis:[PubMed][Scholar]

Outlines

Invitro Release Study of Sodium Salicylate from Lecithin Based Phospholipid Microemulsions

Abstract

Similar Articles

Preparation, Characterization, and Skin Permeation Evaluation of Naproxen Microemulsions for Transdermal Delivery

Development and Ex-Vivo Skin Permeation of Sildenafil Citrate Microemulsion System for Transdermal Delivery

Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels

Preparation and Evaluation of Aceclofenac Topical Microemulsion

Transdermal Delivery of Ketorolac Tromethamine Using Microemulsion Vehicles

Crossmark

Checking

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 1 day ago