Cytotoxic Effects of the Extracts of Iranian Taxus baccata and Cupressus horizentalis on Cancer Cells
Authors
Abstract
It has been reported that several conifers possess cytotoxic activities on some human tumor cell lines. Taxol as a natural cytotoxic compound has been extracted from this family. In a program to screen the cytotoxic effects of natural resources, male and female branchlets, fruit or bark of two different species of Iranian conifers were collected, identified and the cytotoxic effects of their hydroalcoholic extracts on three human tumor cell lines were determined. Different concentrations of extracts were added to cultured cells and incubated for 72 h. Cell survival was evaluated using MTT assay. Extracts from bark of female Taxus baccata showed inhibitory activities against Hela cells. The extracts of the branchlets of male and female T. baccata and branchlets of Cupressus horizentalis showed inhibitory activities against MDA-MB-468 cells, whereas the extracts of branchlets of female T. baccata showed inhibitory activities against KB cells. In conclusion, extract obtained from the bark of Iranian T. baccata showed a comparable cytotoxic effect to doxorubicin against Hela cells.
Highlights
Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines
Esmaeilbeig M, Kouhpayeh SA, Amirghofran Z. An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines. Int J Cancer Manag. 2015;8(5):e4032. doi: https://doi.org/10.17795/ijcp-4032
In-vitro Antimicrobial Activities of Some Iranian Conifers
Afsharzadeh M, Naderinasab M, Tayarani Najaran Z, Barzin M, Emami SA. In-vitro Antimicrobial Activities of Some Iranian Conifers. Iran J Pharm Res. 2013;12(1):e127537. doi: https://doi.org/10.22037/ijpr.2012.1222
Comparison of Anticancer Activity of Hydroalcoholic Extracts of Curcuma longa L., Peganum harmala L., and Boswellia serrata on HeLa cells
Farajian Mashhadi F, Salimi S, Forouzandeh F, Naghsh N. Comparison of Anticancer Activity of Hydroalcoholic Extracts of Curcuma longa L., Peganum harmala L., and Boswellia serrata on HeLa cells. Jundishapur J Nat Pharm Prod. 2017;12(2):e37336. doi: https://doi.org/10.5812/jjnpp.37336
Evaluation of Antimicrobial Activity of Some Medicinal Plants on Human Standard Bacteria and Candida albicans
Fazeli-Nasab B, Rahmani AF, Valizadeh M, Khajeh H, Beigomi M. Evaluation of Antimicrobial Activity of Some Medicinal Plants on Human Standard Bacteria and Candida albicans. Gene Cell Tissue. 2021;8(3):e113092. doi: https://doi.org/10.5812/gct.113092
Cell Toxicity Effect of the Extract of Medicinal Plants against Human Breast (MCF7 and KBR3) Cancer Cell Lines
Mojodi E, Doostabadi MR, Sabbagh SK, Mohammadpanah M, Haghiralsadat BF, et al. Cell Toxicity Effect of the Extract of Medicinal Plants against Human Breast (MCF7 and KBR3) Cancer Cell Lines. Gene Cell Tissue. 2023;10(1):e119837. doi: https://doi.org/10.5812/gct-119837
- Scopus by DOI: 12
Last Update: 3 weeks ago
- Scopus by Title: 12
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 6 days ago
- OpenAlex: 12
Last Update: 6 hours ago
- OpenCitations: 0
Last Update: 4 days ago