Effect of Polymer Grade and Plasticizer Molecular Weights on Viscoelastic Behavior of Coating Solutions
Authors
Abstract
Film coating solutions containing different grades of HPMC (E5, E15 and E50) with and without polyethylene glycol (with various molecular weights) were examined by an oscillatory method, using Haake CV 100 rheometer. Fundamental rheological parameters ( η, G' and G'' ) were measured over the frequency range from 0.04 to 2 Hz. The variation with frequency of the loss tangent (a ratio of viscous to elastic contribution) provides a useful parameter for the characterization of pharmaceutical products. Magnitudes of the loss tangent are discussed with relation to coating solutions made by different grades of polymers and plasticizers.
Highlights
Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
The Effect of Core Surface Tension on Roughness of Film - Coated Tablets
Honary S, Orafai H. The Effect of Core Surface Tension on Roughness of Film - Coated Tablets. Iran J Pharm Res. 2022;2(1):e127611. doi: https://doi.org/10.22037/ijpr.2010.39
STUDY OF FREE-FILMS AND COATED TABLETS BASED ON HPMC AND MICROCRYSTALLINE CELLULOSE, AIMED FOR IMPROVE STABILITY OF MOISTURE-SENSITIVE DRUGS
Abbaspour M, Sharif Makhmalzadeh B, Jalali S. STUDY OF FREE-FILMS AND COATED TABLETS BASED ON HPMC AND MICROCRYSTALLINE CELLULOSE, AIMED FOR IMPROVE STABILITY OF MOISTURE-SENSITIVE DRUGS. Jundishapur J Nat Pharm Prod. 2010;5(1):. doi:
The Effects of Lactose, Microcrystalline Cellulose and Dicalcium Phosphate on Swelling and Erosion of Compressed HPMC Matrix Tablets: Texture Analyzer
Namdeo Tukaram B, Vidaya Rajagopalan I, Sushi Ikumar Shartchandra P. The Effects of Lactose, Microcrystalline Cellulose and Dicalcium Phosphate on Swelling and Erosion of Compressed HPMC Matrix Tablets: Texture Analyzer. Iran J Pharm Res. 2010;9(4):e126087. doi: https://doi.org/10.22037/ijpr.2010.900
The Influence of Various Silicones on the Rheological Parameters of AZG Containing Silicone-Based Gels
Mortazavi SA, Tabandeh H. The Influence of Various Silicones on the Rheological Parameters of AZG Containing Silicone-Based Gels. Iran J Pharm Res. 2022;4(4):e128246. doi: https://doi.org/10.22037/ijpr.2010.638
Preparation and Evaluation of Matrix Containing Lidocaine and Prilocaine for Using in Transdermal Films
Kouchak M, Rezaee S, Moshabeh N, Handali S. Preparation and Evaluation of Matrix Containing Lidocaine and Prilocaine for Using in Transdermal Films. J Rep Pharm Sci. 2019;8(2):e147412. doi: https://doi.org/10.4103/jrptps.JRPTPS_71_18
- Scopus by DOI: 8
Last Update: 3 weeks ago
- Scopus by Title: 8
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 27 minutes ago
- OpenAlex: 5
Last Update: 11 hours ago
- OpenCitations: 3
Last Update: 4 days ago