IJ Pharmaceutical Research
Hypoglycemic Activity of Casearia esculenta Roxb. in Normal and Diabetic Albino Rats
Abstract
The hypoglycemic effect of ethanolic extract of Casearia esculenta was investigated on alloxan induced diabetic rats. The blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment. The ethanolic extract of C. esculenta (250 mg/kg) reduced the blood glucose of normal rat from 85.50±1.22 to 64.67±3.27 mg/dl, 3 h after oral administration of the extract (P<0.05). It also significantly lowered blood glucose level in alloxan induced diabetic rat from 331.67±4.90 to 130.33±6.53 mg/dl, 3 h after oral administration of the extract (P<0.05). The antihyperglycemic activity of C. esculenta was compared with tolbutamide, an oral hypoglycemic agent.
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© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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