Investigating the Anti-Inflammatory and Analgesic Activity of Leaves of Wedelia chinensis (Osbeck) Merr. In Standard Experimental Animal models

How to Cite:Sureshkumar S, Sivakumar T, Nanjan Chandrasekar MJ, Suresh B. Investigating the Anti-Inflammatory and Analgesic Activity of Leaves of Wedelia chinensis (Osbeck) Merr. In Standard Experimental Animal models. Iran J Pharm Res. 2022;5(2):e128274. doi: https://doi.org/10.22037/ijpr.2010.664

Abstract

The ethanolic extract of Wedelia chinensis (EEWC) belonging to the family of Asteraceae was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its by using on carrageenan, mediators such as histamine and serotonin induced paw oedema, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in rats, as well as analgesic activity in mice. It was found that the extract caused an inhibition on the writhing response induced by acetic acid in a dose dependent manner. Dose of 500 mg/kg EEWC and aspirin could block the writhing response by 51.92 % and 68.68 % (p < 0.001), respectively. It was also indicated that the EEWC showed significant antinociceptive action in hot plate reaction time method in mice. This effect was comparable to that of standard drug morphine treated controls, suggesting the central activity of EEWC. Maximum inhibition (56.14 %) was obtained at the dose of 500 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas indomethacin (standard drug) produced 61.65 % of inhibition. In the chronic model (cotton pellet induced granuloma) the EEWC (125,250 and 500 mg/kg) and standard drug showed decreased formation of granuloma tissue by 56.69,34.57,43.30 % and 55.23 % respectively. The results indicate the potent analgesic and anti-inflammatory effects and therapeutic efficacy of Wedelia chinensis extract on animal models which are comparable with those of standard drugs such as Aspirin, Morphine and Indomethacin respectively.

Keywords

Wedelia chinensis

Analgesic activity

Anti-inflammatory effect

cotton pellet-induced granuloma

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 7
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 0
Last Update: 1 week ago
CrossRef: 1
Last Update: 2 hours ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Shanmugam Sureshkumar:[PubMed][Scholar]
Thangavel Sivakumar:[PubMed][Scholar]
Molla Joghee Nanjan Chandrasekar:[PubMed][Scholar]
Bhojraj Suresh:[PubMed][Scholar]

Outlines

Investigating the Anti-Inflammatory and Analgesic Activity of Leaves of Wedelia chinensis (Osbeck) Merr. In Standard Experimental Animal models

Abstract

Crossmark

Checking

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 2 hours ago