The Effect of Aqueous Crocus sativus L. Extract on Intracerebroventricular Streptozotocin-induced Cognitive Deficits in Rat: a Behavioral Analysis
Authors
Abstract
Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment in rats. The beneficial effect of Crocus sativus L. extract (CSE) was evaluated on ICV STZ-induced learning, memory, and cognitive impairment in male rats. For this purpose, rats were injected with ICV STZ bilaterally, on days 1 and 3 (3 mg/kg). The STZ-injected rats received CSE (60 mg/kg; i.p.) every other day, starting one day before surgery, for three weeks. The learning and memory performance was assessed using passive avoidance paradigm, and for spatial cognition evaluation, Y-maze task was used. It was found that CSE-treated STZ-injected rats show higher correct choices and lower errors in Y maze than vehicle-treated STZ-injected rats. In addition, CSE administration significantly attenuated learning and memory impairment in treated STZ-injected group in passive avoidance test. Therefore, these results demonstrate the effectiveness of CSE in preventing the cognitive deficits caused by ICV STZ in rats and its potential in the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD).
Highlights
Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat
Elahdadi-Salmani M, Khorshidi M, Ozbaki J. Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat. Zahedan J Res Med Sci. 2015;17(3):-. doi: https://doi.org/10.17795/zjrms1279
The therapeutic effect of crocin on ketamine-induced retrograde amnesia in rats
Yousefvand N, Doosti H, Pourmotabbed A, Nedaei SE. The therapeutic effect of crocin on ketamine-induced retrograde amnesia in rats. J Kermanshah Univ Med Sci. 2016;20(2):e69704. doi: https://doi.org/10.22110/jkums.v20i2.2790
Neuroprotective Effects of Alhagi maurorum Extract in a Rat Model of Mild Cognitive Impairment
Karimi O, Shamsizadeh A, Hassanshahi J, Taghipour Z, Khademalhosseini M, et al. Neuroprotective Effects of Alhagi maurorum Extract in a Rat Model of Mild Cognitive Impairment. Jundishapur J Nat Pharm Prod. 2025;20(3):e160528. doi: https://doi.org/10.5812/jjnpp-160528
The therapeutic effect of Crocin on Scopolamine induced retrograde amnesia in male rats
Nedaei SE, Pourmotabbed A, Aeenfar M, Seifi Z. The therapeutic effect of Crocin on Scopolamine induced retrograde amnesia in male rats. J Kermanshah Univ Med Sci. 2012;16(2):e78821. doi:
Withania coagulans Protects Striatum from Oxidative Damages Induced by Global Brain Ischemia in Rat
Mahmoudzadeh-Sagheb H, Heidari Z, Sarbishegi M. Withania coagulans Protects Striatum from Oxidative Damages Induced by Global Brain Ischemia in Rat. Jundishapur J Nat Pharm Prod. 2018;13(2):e65051. doi: https://doi.org/10.5812/jjnpp.65051
More by these authors
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 30
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 6 days ago
- OpenAlex: 27
Last Update: 5 hours ago
- OpenCitations: 0
Last Update: 4 days ago