Determination of Isosorbide Dinitrate in Serum by GasChromatography with New Generation of Electron CaptureDetector and its Application in Pharmacokinetic Study

How to Cite:Mahmoudian M, Falahatpishe H, Gholamine B, Tayebi L. Determination of Isosorbide Dinitrate in Serum by GasChromatography with New Generation of Electron CaptureDetector and its Application in Pharmacokinetic Study. Iran J Pharm Res. 2022;8(4):e128645. doi: https://doi.org/10.22037/ijpr.2010.818

Abstract

Isosorbide dinitrate (ISDN) is an effective drug in treatment of angina pectoris. In this study a new generation of electron capture detector (non-radioactive) with a short, non-polar and wide-bore column was used for analysis of ISDN in human serum. ISDN was extracted from serum by a mixture of ether and ethyl acetate and concentrated at room temperature. The method was linear between 5-50 ng/mL. Recovery and accuracy were 99-108% and greater than 90%, respectively, and inter-day precision was lower than 13%. Pharmacokinetic parameters were analyzed after oral administrations of Isocor 40 mg sustained release tablet in comparison with Isoket Retard 40. The statistical results obtained from comparison of Cmax, Tmax and AUC parameters showed no significant difference between these two productsand therefor they were reported to be bioequivalent. Further more, the method used was found to be sensitive and accurate in pharmacokinetic studies.

Keywords

Serum

pharmacokinetic

Electron capture detector

Gas chromatography

Isosorbide dinitrate

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Author(s):

Massoud Mahmoudian:[PubMed][Scholar]
Hamidreza Falahatpishe:[PubMed][Scholar]
Babak Gholamine:[PubMed][Scholar]
Ladan Tayebi:[PubMed][Scholar]

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Determination of Isosorbide Dinitrate in Serum by GasChromatography with New Generation of Electron CaptureDetector and its Application in Pharmacokinetic Study

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