Evaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima andJuniperus sabina Extracts Against a Panel of Cancer Cells

Hojjat Sadeghi-aliabadi; Ahmad Emami; Morteza Saidi; Babak Sadeghi; Abbas Jafarian

doi:10.22037/ijpr.2010.823

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.823

Evaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima andJuniperus sabina Extracts Against a Panel of Cancer Cells

Author(s):

Hojjat Sadeghi-aliabadi^{1, 2,*},

Ahmad Emami³,

Morteza Saidi¹,

Babak Sadeghi¹,

Abbas Jafarian²

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3Department of Pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

IJ Pharmaceutical Research:Vol. 8, issue 4; 281-286

Published online:Nov 20, 2010

Article type:Research Article

Received:Nov 01, 2008

Accepted:Jan 01, 2009

How to Cite:Sadeghi-aliabadi H, Emami A, Saidi M, Sadeghi B, Jafarian A. Evaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima andJuniperus sabina Extracts Against a Panel of Cancer Cells. Iran J Pharm Res. 2022;8(4):e128650. doi: https://doi.org/10.22037/ijpr.2010.823

Abstract

Isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. It has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. Here branchlets and berries of Juniperus foetidissima and J. sabina were collected, dried and ethanol extracts of them obtained using percolation. Extracts were dried in reduced pressure and cytotoxic effects of different concentrations (5, 10, 20 µg/ml) were evaluated by MTT assay against three tumor cell lines (Hela, KB, MDA-MB-468), using ELISA at 540 nm. The extracts of the branchlets of male and female of J.foetidissima and berries extract of J. sabina showed inhibitory activities against KB cells. Extracts of male branchlets of J. foetidissima and berries extract of J. sabina were cytotoxic (cell survival less than 50%) against Hela cell line. Regarding to MDA-MB-468, only the extract of male branchlets of J. foetidissima was cytotoxic. Extracts of J. sabina were not cytotoxic at tested concentrations. According to the results obtained by MTT assay, KB cells seem to be much more sensitive than the other cell lines.

Keywords

Comparative Analysis of Chemical Profile, Antioxidant, In-vitro and In-vivo Antidiabetic Activities of Juniperus foetidissima Willd. and Juniperus sabina L.

Nilüfer Orhan,

Didem Deliorman Orhan,

Alper Gökbulut,

Mustafa Aslan,

Fatma Ergun

Orhan N, Deliorman Orhan D, Gökbulut A, Aslan M, Ergun F. Comparative Analysis of Chemical Profile, Antioxidant, In-vitro and In-vivo Antidiabetic Activities of Juniperus foetidissima Willd. and Juniperus sabina L.. Iran J Pharm Res. 2017;16(Suppl):e124892. doi: https://doi.org/10.22037/ijpr.2017.1962

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Nilüfer Orhan,

Burçin Özüpek,

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Gök HN, Orhan N, Özüpek B, Pekacar S, Selvi ŞN, et al. Standardization of Juniperus macrocarpa Sibt. & Sm. and Juniperus excelsa M. Bieb. Extracts with Carbohydrate Digestive Enzyme Inhibitory and Antioxidant Activities. Iran J Pharm Res. 2021;20(3):e124307. doi: https://doi.org/10.22037/ijpr.2021.114838.15055

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Emami SA, Abedindo BF, Hassanzadeh-Khayyat M. Antioxidant Activity of the Essential Oils of Different Parts of Juniperus excelsa M. Bieb. subsp. excelsa and J. excelsa M. Bieb. subsp. polycarpos (K. Koch) Takhtajan (Cupressaceae). Iran J Pharm Res. 2011;10(4):e126005. doi: https://doi.org/10.22037/ijpr.2011.985

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In-vitro Antimicrobial Activities of Some Iranian Conifers

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Mahboobe Naderinasab,

Zahra Tayarani Najaran,

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Seyed Ahmad Emami

Afsharzadeh M, Naderinasab M, Tayarani Najaran Z, Barzin M, Emami SA. In-vitro Antimicrobial Activities of Some Iranian Conifers. Iran J Pharm Res. 2013;12(1):e127537. doi: https://doi.org/10.22037/ijpr.2012.1222

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Cytotoxic Effects of the Extracts of Iranian Taxus baccata and Cupressus horizentalis on Cancer Cells

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Seyed Ahmad Emam,

Morteza Saeidi,

Abbas Jafarian

Sadeghi-aliabadi H, Emam SA, Saeidi M, Jafarian A. Cytotoxic Effects of the Extracts of Iranian Taxus baccata and Cupressus horizentalis on Cancer Cells. Iran J Pharm Res. 2022;2(2):e127620. doi: https://doi.org/10.22037/ijpr.2010.21

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Author(s):

Hojjat Sadeghi-aliabadi:[PubMed][Scholar]
Ahmad Emami:[PubMed][Scholar]
Morteza Saidi:[PubMed][Scholar]
Babak Sadeghi:[PubMed][Scholar]
Abbas Jafarian:[PubMed][Scholar]

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Evaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima andJuniperus sabina Extracts Against a Panel of Cancer Cells

Abstract

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